Highly efficient CuBr-catalyzed cross-dehydrogenative coupling (CDC) between tetrahydroisoquinolines and activated methylene compounds

被引：181
作者：
Li, ZP [1 ]
Li, CJ [1 ]
机构：
[1] McGill Univ, Dept Chem, Montreal, PQ H3A 2K6, Canada
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2005年 / 2005卷 / 15期
关键词：
amine; cross coupling; C-H activation; C-CN bond cleavage; copper catalyst;
D O I：
10.1002/ejoc.200500226
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel and efficient C-C bond-formation method was developed: the cross-dehydrogenative coupling (CDC) reaction catalyzed by copper bromide in the presence of an oxidizing reagent, tBuOOH. The CDC reaction provides a simple and efficient catalytic method to construct beta-amino diesters and beta-dicyano amines by a combination of two different sp(3) C-H bonds followed by C-C bond formation. (c) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005).
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收藏
页码：3173 / 3176
页数：4
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