Survival of patient with late onset hepatic failure by living-related liver transplantation from maternal donor with incompatible blood type

被引:1
作者
Kojima, A [1 ]
Takagi, H [1 ]
Abe, T [1 ]
Sakurai, S [1 ]
Sohara, N [1 ]
Kakizaki, S [1 ]
Nagamine, T [1 ]
Mori, M [1 ]
Matsunami, M [1 ]
Ikegami, T [1 ]
Hashikura, Y [1 ]
Kawasaki, S [1 ]
Makuuchi, M [1 ]
机构
[1] Gunma Univ, Sch Med, Dept Internal Med 1, Maebashi, Gumma 3718511, Japan
关键词
living-related liver transplantation; incompatible blood type; late onset hepatic failure;
D O I
10.1007/s005350050197
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
A 14-year-old girl with blood type B with late onset hepatic failure (LOHF) of unknown cause has survived through living-related liver transplantation (LRLT). No hepatitis virus, including HAV, HBV, HCV, and HGV, was positive at the onset of LOHF. Autoimmune hepatitis was thought to be the cause because of positive results for serum anti-nuclear antibody at 80 times dilution and elevated gammaglobulin, but treatment with glucocorticoid did not suppress the progressive hepatic failure. Supportive therapy, including pulse therapy with Ig methylprednisolone for 3 days, ursodesoxycholic acid, branched-chain amino acid, and azathioprine did not resolve the hepatic failure. She was treated by repeated plasmapheresis and plasma absorption for 10 months, and then received the left lobe of her mother's liver. (Her mother's blood type was AB). The patient had been well, being treated with tacrolimus and prednisolone, although the serum titer of anti-blood type B antibody was high just after LRLT and mild liver dysfunction continued for more than 3 years after LRLT. Follow-up biopsy 3 years after LRLT revealed chronic hepatitis and progression to liver cirrhosis. Re-transplantation is now under consideration; the patient is now aged 19 years.
引用
收藏
页码:899 / 903
页数:5
相关论文
共 12 条
[1]   Hepatitis G virus infection in patients with hepatitis C virus infection undergoing liver transplantation [J].
Berenguer, H ;
Terrault, NA ;
Piatak, M ;
Yun, A ;
Kim, JP ;
Lau, JYN ;
Lake, JR ;
Roberts, JR ;
Ascher, NL ;
Ferrell, L ;
Wright, TL .
GASTROENTEROLOGY, 1996, 111 (06) :1569-1575
[2]   THE USE OF ABO-INCOMPATIBLE GRAFTS IN LIVER-TRANSPLANTATION - A LIFESAVING PROCEDURE IN HIGHLY SELECTED PATIENTS [J].
FARGES, O ;
KALIL, AN ;
SAMUEL, D ;
SALIBA, F ;
ARULNADEN, JL ;
DEBAT, P ;
BISMUTH, A ;
CASTAING, D ;
BISMUTH, H .
TRANSPLANTATION, 1995, 59 (08) :1124-1133
[3]  
HASHIKURA Y, 1995, J HEP BIL PANCR SURG, V2, P52
[4]  
KAWASAKI S, 1995, TRANSPLANT P, V27, P1170
[5]  
Kew MC, 1996, LANCET, V348, pSII10
[6]   Infection with hepatitis GB virus C in patients on maintenance hemodialysis [J].
Masuko, K ;
Mitsui, T ;
Iwano, K ;
Yamazaki, C ;
Okuda, K ;
Meguro, T ;
Murayama, N ;
Inoue, T ;
Tsuda, F ;
Okamoto, H ;
Miyakawa, Y ;
Mayumi, M .
NEW ENGLAND JOURNAL OF MEDICINE, 1996, 334 (23) :1485-1490
[7]   Posttransplantation chronic hepatitis in fulminant hepatic failure [J].
Mohamed, R ;
Hubscher, SG ;
Mirza, DF ;
Gunson, BK ;
Mutimer, DJ .
HEPATOLOGY, 1997, 25 (04) :1003-1007
[8]   SUCCESSFUL USE OF AN ENHANCED IMMUNOSUPPRESSIVE PROTOCOL WITH PLASMAPHERESIS FOR ABO-INCOMPATIBLE MISMATCHED GRAFTS IN LIVER-TRANSPLANT RECIPIENTS [J].
MOR, E ;
SKERRETT, D ;
MANZARBEITIA, C ;
SHEINER, PA ;
SCHWARTZ, ME ;
EMRE, S ;
THUNG, SN ;
MILLER, CM .
TRANSPLANTATION, 1995, 59 (07) :986-990
[9]   A novel DNA virus (TTV) associated with elevated transaminase levels in posttransfusion hepatitis of unknown etiology [J].
Nishizawa, T ;
Okamoto, H ;
Konishi, K ;
Yoshizawa, H ;
Miyakawa, Y ;
Mayumi, M .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1997, 241 (01) :92-97
[10]   Hepatitis G virus in patients with cryptogenic liver disease undergoing liver transplantation [J].
Pessoa, MG ;
Terrault, NA ;
Ferrell, LD ;
Kim, JP ;
Kolberg, J ;
Detmer, J ;
Collins, ML ;
Yun, AJ ;
Viele, M ;
Lake, JR ;
Roberts, JP ;
Ascher, NL ;
Wright, TL .
HEPATOLOGY, 1997, 25 (05) :1266-1270