Human Male infertility: A Complex Multifactorial Phenotype

被引：58
作者：
Singh, Kiran [1 ]
Jaiswal, Deepika [1 ]
机构：
[1] Banaras Hindu Univ, Dept Mol & Human Genet, Varanasi 221005, Uttar Pradesh, India
来源：
REPRODUCTIVE SCIENCES | 2011年 / 18卷 / 05期
关键词：
multifactorial; azoospermia; epigenetics; MicroRNA; HPG axis; HUMAN Y-CHROMOSOME; INTRACYTOPLASMIC SPERM INJECTION; ANDROGEN-RECEPTOR GENE; ZINC-SULFATE; FOLIC-ACID; MEN; SPERMATOZOA; MUTATION; C677T; SPERMATOGENESIS;
D O I：
10.1177/1933719111398148
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Infertility is a major reproductive health problem affecting 10% to 15% of couples, with approximately equal contributions. Spermatogenesis is a dynamic and multistep process of male germ cell proliferation and differentiation by which spermatozoa are produced from primordial germ cells. The causes of spermatogenic defects in infertile men are multifactorial and many environmental, nutritional, behavioral and genetic factors affect male infertility. In most of the infertile cases, the underlying mechanisms remain obscure. Genomics and proteomics offer new tools for better understanding the genetics of male infertility. The current review provides insights into the plausible chromosomal, genetic and epigenetic alterations, which may result into infertile phenotype.
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收藏
页码：418 / 425
页数：8
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