Immune Surveillance by Myeloid-Derived Suppressor Cells in Liver Diseases

被引：2

作者：

Sehgal, Rashi ^{[1
,2
]}

Kaur, Navkiran ^{[2
]}

Ramakrishna, Gayatri ^{[1
]}

Trehanpati, Nirupma ^{[1
]}

机构：

[1] Inst Liver & Biliary Sci, Dept Mol & Cellular Med, New Delhi, India

[2] Amity Univ, Amity Inst Biotechnol AIB, Noida, India

来源：

DIGESTIVE DISEASES | 2022年 / 40卷 / 03期

关键词：

Myeloid-derived suppressor cells; Immunosuppression; Granulocytic myeloid-derived suppressor cells; Monocytic myeloid-derived suppressor cells; Sepsis; HEPATIC STELLATE CELLS; HEPATOCELLULAR-CARCINOMA; T-CELLS; SELF-RENEWAL; STEM-CELLS; EXPRESSION; CANCER; DIFFERENTIATION; ACCUMULATION; EXPANSION;

D O I：

10.1159/000517459

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background: Myeloid-derived suppressor cells (MDSCs) are immunosuppressive in nature, originate in the bone marrow, and are mainly found in the blood, spleen, and liver. In fact, liver acts as an important organ for induction and accumulation of MDSCs, especially during infection, inflammation, and cancer. In humans and rodents, models of liver diseases revealed that MDSCs promote regeneration and drive the inflammatory processes, leading to hepatitis, fibrogenesis, and cirrhosis, ultimately resulting in hepatocellular carcinoma. Summary: This brief review is focused on the in-depth understanding of the key molecules involved in the expansion and regulation of MDSCs and their underlying immunosuppressive mechanisms in liver diseases. Key Message: Modulated MDSCs can be used for therapeutic purposes in inflammation, cancer, and sepsis.

引用

页码：301 / 312

页数：12

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