Facile Coordination-Precipitation Route to Insoluble Metal Roussin's Black Salts for NIR-Responsive Release of NO for Anti-Metastasis

被引：31
作者：
Chen, Lijuan [1 ]
He, Qianjun [2 ]
Lei, Minyi [1 ]
Xiong, Liwei [3 ]
Shi, Kun [1 ]
Tan, Liwei [1 ]
Jin, Zhaokui [2 ]
Wang, Tianfu [2 ]
Qian, Zhiyong [1 ]
机构：
[1] Sichuan Univ, West China Hosp, Collaborat Innovat Ctr Biotherapy, State Key Lab Biotherapy & Canc Ctr, Chengdu 610041, Sichuan, Peoples R China
[2] Shenzhen Univ, Sch Biomed Engn, Hlth Sci Ctr, Natl Reg Key Technol Engn Lab Med Ultrasound,Guan, Shenzhen 518060, Guangdong, Peoples R China
[3] Wuhan Inst Technol, Hubei Key Lab Plasma Chem & Adv Mat, Wuhan 430073, Hubei, Peoples R China
来源：
ACS APPLIED MATERIALS & INTERFACES | 2017年 / 9卷 / 42期
基金：
中国国家自然科学基金;
关键词：
controlled release; gas therapy; NO donor; Roussin's black salts; antimetastasis; near infrared light; NO-releasing molecules; NITRIC-OXIDE RELEASE; GENERATION; NANOMEDICINE;
D O I：
10.1021/acsami.7b11325
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
A facile and general coordination-precipitation method is developed to synthesize insoluble metal Roussin's black salts (Me-RBSs) as a new type of NIR-responsive NORMs. The weak-field ligand coordination of metal(+)-RBS- brings a NIR absorption effect of Me-RBSs, and further gives rise to the NIR adsorption-dependent NIR-responsive NO release profile. Intratumoral NIR-responsive release of NO effectively inhibits the growth and metastasis of the metastatic breast cancer. Aqueous insolubility of Me-RBSs ensures lower cytotoxicity and higher thermostability compared with traditional soluble RBSs. This work establishes a new class of NIRsensitive NO donors, and may spark new inspiration for designing intelligent gas-releasing molecules.
引用
收藏
页码：36473 / 36477
页数：5
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