Long noncoding RNA GAS5 affects cell proliferation and predicts a poor prognosis in patients with colorectal cancer

被引：199

作者：

Yin, Dandan ^{[1
,2
,3
]}

He, Xuezhi ^{[2
,3
]}

Zhang, Erbao ^{[2
,3
]}

Kong, Rong ^{[4
]}

De, Wei ^{[2
,3
]}

Zhang, Zhihong ^{[2
,3
,5
]}

机构：

[1] Southeast Univ, Affiliated Hosp 2, Canc Res & Therapy Ctr, Nanjing, Jiangsu, Peoples R China

[2] Nanjing Med Univ, Dept Biochem, Nanjing 210029, Jiangsu, Peoples R China

[3] Nanjing Med Univ, Dept Mol Biol, Nanjing 210029, Jiangsu, Peoples R China

[4] Subei Peoples Hosp, Lab Ctr, Yangzhou, Jiangsu, Peoples R China

[5] Nanjing Med Univ, Affiliated Hosp 1, Dept Pathol, Nanjing 210029, Jiangsu, Peoples R China

来源：

MEDICAL ONCOLOGY | 2014年 / 31卷 / 11期

关键词：

GAS5; Long noncoding RNAs; Proliferation; Colorectal cancer; GENE-EXPRESSION; GROWTH-ARREST; TUMOR-GROWTH; APOPTOSIS; HOTAIR; GENOME;

D O I：

10.1007/s12032-014-0253-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Colorectal cancer (CRC) is the third most common type of cancer worldwide. Recent studies have shown that lncRNAs play important roles in carcinogenesis. The aim of this study was to explore the role of lncRNA GAS5 in CRC. Real-time PCR was performed to investigate the expression of GAS5 in tumor tissues and corresponding non-tumor colorectal tissues from 66 patients with CRC. The lower expression of GAS5 was significantly correlated with large tumor size, low histological grade and advanced TNM stage. Multivariate analyses revealed that GAS5 expression served as an independent predictor for overall survival (P = 0.034). Further experiments revealed that overexpressed GAS5 significantly repressed the proliferation both in vitro and in vivo. In conclusion, our results suggest that GAS5, as a growth regulator, may serve as a candidate prognostic biomarker in human colorectal cancer.

引用

页码：1 / 8

页数：8

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