Prognostic significance of matrix metalloproteinase-1 levels in peripheral plasma and tumour tissues of lung cancer patients

被引：49

作者：

Li, Min ^{[1
,2
]}

Xiao, Ting ^{[1
,2
]}

Zhang, Ying ^{[1
,2
]}

Feng, Lin ^{[1
,2
]}

Lin, Dongmei ^{[2
,3
]}

Liu, Yu ^{[1
,2
]}

Mao, Yousheng ^{[2
,4
]}

Guo, Suping ^{[1
,2
]}

Han, Naijun ^{[1
,2
]}

Di, Xuebing ^{[1
,2
]}

Zhang, Kaitai ^{[1
,2
]}

Cheng, Shujun ^{[1
,2
]}

Gao, Yanning ^{[1
,2
]}

机构：

[1] Peking Union Med Coll, Canc Inst Hosp, Dept Etiol & Carcinogenesis, State Key Lab Mol Oncol, Beijing 100021, Peoples R China

[2] Chinese Acad Med Sci, Beijing 100021, Peoples R China

[3] Peking Union Med Coll, Canc Hosp, Dept Pathol, Beijing 100021, Peoples R China

[4] Peking Union Med Coll, Canc Hosp, Dept Thorac Surg, Beijing 100021, Peoples R China

来源：

LUNG CANCER | 2010年 / 69卷 / 03期

关键词：

Lung cancer; MMP-1; Enzyme-linked immunosorbance assay; Immunohistochemical staining; Prognosis; Survival; POOR-PROGNOSIS; BREAST-CANCER; EXPRESSION; OVEREXPRESSION; PROGRESSION; CARCINOMA; MMP-1; CELLS; MATRIX-METALLOPROTEINASE-9; POLYMORPHISM;

D O I：

10.1016/j.lungcan.2009.12.007

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Matrix metalloproteinase-1 (MMP-1) participates in a variety of physiological and pathological processes. We previously found that MMP-1 was one of the lung cancer-related proteins detectable in peripheral blood. To validate our preliminary observations and explore the clinical significance of MMP-1 for lung cancer further, we carried out the present study. The concentrations of MMP-1 in circulating plasma specimens of 170 lung cancer patients and 70 healthy individuals were measured by an enzyme-linked immunosorbance assay. The expression status of the MMP-1 in archival tissue samples from 122 lung cancer patients was examined by immunohistochemical analysis. The correlation between the MMP-1 levels and prognosis of the lung cancer patients was then assessed statistically. Protein levels of MMP-1 were considerably raised in the plasma from lung cancer patients relative to those in healthy controls. The high plasma MMP-1 levels were associated with advanced-stage of the disease and significantly lower overall survival rate of the patients. Coincidently, MMP-1 protein extraordinarily overexpressed in the tumour tissues of lung cancer; and the up-regulated MMP-1 was associated with the progression (including tumour size, staging and lymphatic invasion), especially with decreased survival rate of the patients. Statistic analysis revealed that MMP-1 protein levels had an independent influence on survival. MMP-1 levels were elevated in both tumour tissue and blood; the latter may serve as an independent predictor for survival of lung cancer patients. MMP-1 protein levels in plasma/serum thus represent a potential and clinically relevant biomarker for the prognosis of patients with lung cancers. (C) 2009 Elsevier Ireland Ltd. All rights reserved.

引用

页码：341 / 347

页数：7

共 33 条

[1] Expression of collagenases-1 and -3 and their inhibitors TIMP-1 and -3 correlates with the level of invasion in malignant melanomas [J].