Extracellular vesicles in liver disease and potential as biomarkers and therapeutic targets

被引：249
作者：
Szabo, Gyongyi [1 ]
Momen-Heravi, Fatemeh [1 ]
机构：
[1] Univ Massachusetts, Dept Med, Sch Med, LRB208,364 Plantat St, Worcester, MA 01605 USA
来源：
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY | 2017年 / 14卷 / 08期
关键词：
HEPATIC STELLATE CELLS; HEPATOCELLULAR-CARCINOMA; CIRCULATING MICROPARTICLES; EXOSOMES MEDIATE; EMERGING ROLES; MICROVESICLES; EXPRESSION; RELEASE; MICRORNAS; SERUM;
D O I：
10.1038/nrgastro.2017.71
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Extracellular vesicles (EVs) are membranous vesicles originating from different cells in the liver. The pathophysiological role of EVs is increasingly recognized in liver diseases, including alcoholic liver disease, NAFLD, viral hepatitis and hepatocellular carcinoma. EVs, via their cargo, can provide communication between different cell types in the liver and between organs. EVs are explored as biomarkers of disease and could also represent therapeutic targets and vehicles for treatment delivery. Here, we review advances in understanding the role of EVs in liver diseases and discuss their utility in biomarker discovery and therapeutics.
引用
收藏
页码：455 / 466
页数：12
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