Optimization of a biocatalytic single-step alkene cleavage of aryl alkenes

被引：19

作者：

Mang, Harald

Gross, Johannes

Lara, Miguel

Goessler, Christian

Schoemaker, Hans E.

Guebitz, Georg M.

Kroutil, Wolfgang

机构：

[1] Graz Univ, Dept Chem Organ & Bioorgan Chem, A-8010 Graz, Austria

[2] Graz Univ, Dept Chem Organ & Bioorgan Chem, Res Ctr Biocatalysis Appl, A-8010 Graz, Austria

[3] DSM Res Life Sci Product, NL-6160 MD Geleen, Netherlands

[4] Tech Univ, Res Ctr Appl Biocatalysis, Inst Environm Biotechnol, A-8010 Graz, Austria

来源：

TETRAHEDRON | 2007年 / 63卷 / 16期

基金：

奥地利科学基金会;

关键词：

D O I：

10.1016/j.tet.2007.02.034

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The oxidative cleavage of a C=C double bond adjacent to an aryl moiety was achieved in the presence of a protein preparation of Trametes hirsuta G FCC 047 to yield the corresponding aldehydes. Molecular oxygen was the only oxidant required. All positive substrates had a C=C bond conjugated to an aromatic system, all other compounds tested not fulfilling this requirement were non-substrates. The optimum reaction conditions are 20 degrees C, pH 6-6.5, 15% v/v ethanol as co-solvent at an apparent oxygen pressure of 2 bar. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：3350 / 3354

页数：5

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