Synthesis, molecular docking, and inhibitory activity of a Ni Schiff-base complex against urease

被引：16
作者：
Cui, Yong Ming [1 ,2 ]
Yan, Wen Xuan [3 ]
Cai, Ying Jie [1 ]
Chen, Wu [1 ]
Zhu, Hai Liang [1 ,2 ]
机构：
[1] Wuhan Text Univ, Minist Educ, Engn Res Ctr Clean Prod Text Printing, Wuhan 430073, Peoples R China
[2] Nanjing Univ, State Key Lab Pharmaceut Biotechnol, Nanjing 210093, Peoples R China
[3] Lib Wuhan Text Univ, Wuhan 430073, Peoples R China
来源：
JOURNAL OF COORDINATION CHEMISTRY | 2010年 / 63卷 / 21期
关键词：
Schiff base; Molecular docking; Urease; Inhibitor; TRANSITION-METAL-COMPLEXES; JACK-BEAN UREASE; CRYSTAL-STRUCTURES; LIGANDS; COPPER(II); REACTIVITY; CU(II); ACID;
D O I：
10.1080/00958972.2010.517268
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A Ni(II) Schiff-base complex, Ni(C14H10NOBr2)2, was synthesized and structurally characterized by single-crystal X-ray analysis. Its inhibitory activity against Helicobacter pylori urease was evaluated in vitro and showed strong inhibitory activity against H. pylori urease compared with acetohydroxamic acid (IC50 = 42.12 mu mol L-1), which is a positive reference. A docking analysis using the autodock 4.0 program could explain the inhibitory activity of the complex against urease.
引用
收藏
页码：3706 / 3713
页数：8
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