Beneficial Effect of a Low Dose of Ethanol on Liver Function and Serum Urate in Rats Fed a High-Fat Diet

被引：13

作者：

Osaki, Aimi ^{[1
]}

Okazaki, Yukako ^{[2
]}

Kimoto, Akiko ^{[1
]}

Izu, Hanae ^{[3
]}

Kato, Norihisa ^{[1
]}

机构：

[1] Hiroshima Univ, Grad Sch Biosphere Sci, Higashihiroshima 7398528, Japan

[2] Fuji Womens Univ, Fac Human Life Sci, Ishikari, Hokkaido 0613204, Japan

[3] Natl Res Inst Brewing, Higashihiroshima 7390046, Japan

来源：

JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY | 2014年 / 60卷 / 06期

关键词：

ethanol; liver function; urate; high-fat diet; rat; METABOLIC SYNDROME; ANIMAL-TISSUES; ALCOHOL; DISEASE; HYPERTENSION; CONSUMPTION; PROTEIN; HEALTH; GROWTH; ACID;

D O I：

10.3177/jnsv.60.408

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

This study investigated the effects of the consumption of 1% or 2% (v/v) ethanol in drinking water for 12 wk on rats fed a high-fat diet. Body weight gain, food intake, and fluid intake were unaffected by ethanol intake. Adipose tissue weight, and serum glucose and lipids were unaffected. Compared to the control (no ethanol), 1% ethanol intake significantly reduced serum levels of alanine aminotransferase (ALT), lactate dehydrogenase (LDH), and ammonia (p<0.05), whereas 2% ethanol intake did so to a lesser extent. Serum urate was significantly lower in both the 1% and 2% ethanol groups than that in the control group (p<0.05). The results suggest a low dose of ethanol has beneficial effects on liver function and serum urate in rats fed a high-fat diet.

引用

页码：408 / 412

页数：5

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