Polycaprolactone Nanofibers Containing Vascular Endothelial Growth Factor-Encapsulated Gelatin Particles Enhance Mesenchymal Stem Cell Differentiation and Angiogenesis of Endothelial Cells

被引：53

作者：

Jiang, Yong-Chao ^{[1
,2
,3
,4
]}

Wang, Xiao-Feng ^{[1
,2
]}

Xu, Yi-Yang ^{[1
,3
,4
]}

Qiao, Yu-Hui ^{[1
,2
]}

Guo, Xin ^{[1
,2
]}

Wang, Dong-Fang ^{[1
,2
]}

Li, Qian ^{[1
]}

Turng, Lih-Sheng ^{[3
,4
]}

机构：

[1] Zhengzhou Univ, Natl Ctr Int Res Micronano Molding Technol, 100 Kexue Ave, Zhengzhou 450001, Henan, Peoples R China

[2] Zhengzhou Univ, Sch Mech & Engn, 100 Kexue Ave, Zhengzhou 450001, Henan, Peoples R China

[3] Univ Wisconsin, Dept Mech Engn, 1513 Univ Ave, Madison, WI 53706 USA

[4] Univ Wisconsin, Wisconsin Inst Discovery, 1513 Univ Ave, Madison, WI 53706 USA

来源：

BIOMACROMOLECULES | 2018年 / 19卷 / 09期

基金：

美国国家科学基金会;

关键词：

DRUG-DELIVERY; COMPOSITE SCAFFOLDS; TISSUE; NANOPARTICLES; BONE; RELEASE; SYSTEM; CHALLENGES; BEHAVIOR;

D O I：

10.1021/acs.biomac.8b00870

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

During the regeneration of tissues and organs, growth factors (GFs) play a vital role by affecting cell behavior. However, because of the low half-life time and quick degradation of GFs, their stimulations on cells are relatively short and discontinuous. In this study, a releasing scaffold platform, consisting of polycaprolactone (PCL) nanofibers and vascular endothelial growth factor (VEGF)-encapsulated gelatin particles, was developed to extend the influence of GFs on mesenchymal stem cells (MSCs) and endothelial cells (ECs). The results showed that this kind of scaffold can direct the differentiation of MSCs to ECs and maintain the stability of the tubular structure, an indicator of the angiogenesis ability of ECs, for an extended period of time. Therefore, the results suggest the potential application of PCL/VEGF-encapsulated gelatin particles (PCL/VGPs) as a growth factor (GF)-releasing scaffold platform in vascular tissue engineering.

引用

页码：3747 / 3753

页数：7