Association of Apolipoprotein E (ApoE) Polymorphism with Alzheimer's Disease in Chinese Population

被引：15

作者：

Zheng, Lingling ^{[1
,2
]}

Duan, Jianzhong ^{[1
,2
]}

Duan, Xiaoling ^{[1
,2
]}

Zhou, Weitao ^{[1
,2
]}

Chen, Chunjiang ^{[1
,2
]}

Li, Yanhua ^{[1
,2
]}

Chen, Jie ^{[1
,2
]}

Zhou, Weihui ^{[1
,2
]}

Wang, Yan-Jiang ^{[3
,4
]}

Li, Tingyu ^{[1
,2
]}

Song, Weihong ^{[1
,2
,5
]}

机构：

[1] Chongqing Med Univ, Childrens Hosp, Chongqing City Key Lab Translat Med Res Cognit De, Chongqing, Peoples R China

[2] Chongqing Med Univ, Childrens Hosp, Minist Educ, Key Lab Child Dev & Disorders, Chongqing, Peoples R China

[3] Third Mil Med Univ, Daping Hosp, Dept Neurol, Chongqing, Peoples R China

[4] Third Mil Med Univ, Daping Hosp, Ctr Clin Neurosci, Chongqing, Peoples R China

[5] Univ British Columbia, Dept Psychiat, Townsend Family Labs, 2255 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada

来源：

CURRENT ALZHEIMER RESEARCH | 2016年 / 13卷 / 08期

基金：

加拿大健康研究院; 中国国家自然科学基金;

关键词：

Alzheimer's disease; apolipoprotein E; China; genotype; polymorphism; population; GENOME-WIDE ASSOCIATION; CORONARY-HEART-DISEASE; E GENOTYPE; E GENE; PLASMA-LIPOPROTEINS; IDENTIFIES VARIANTS; COMMON VARIANTS; ALLELE; CHOLESTEROL; SEQUENCE;

D O I：

10.2174/1567205013666160401115307

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Apolipoprotein E (ApoE) plays a vital role in cholesterol metabolism and its allele polymorphisms have been associated with several diseases including Alzheimer's disease (AD). There are few systematic studies on ApoE polymorphism and its association with AD in Chinese population. To examine this issue, participants included 4251 subjects and 404 AD patients with 390 healthy elderly residing in Chongqing city were genotyped. The results showed that the epsilon 3 allele presented the highest frequency (82%), followed by epsilon 4 (6.25%) and epsilon 2 (11.75%) in general population. epsilon 3/epsilon 3 genotype carriers are the most common ones (64.19%) and the epsilon 4/epsilon 4 had the lowest frequency (0.59%). The frequency of ApoE epsilon 4 allele frequency in AD (15.35%) was significantly higher than control (10.00%). Those carriers of two epsilon 4 allele have five time higher risk to develop AD. Our study demonstrate that ApoE epsilon 4 allele is a risk factor of AD for Chinese population.

引用

页码：912 / 917

页数：6

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