Practical One-Pot Synthesis of Secondary Amines by Zinc-Catalyzed Reductive Amination

被引：61
作者：
Enthaler, Stephan [1 ]
机构：
[1] Tech Univ Berlin, Dept Chem, Cluster Excellence Unifying Concepts Catalysis, D-10623 Berlin, Germany
来源：
CATALYSIS LETTERS | 2011年 / 141卷 / 01期
关键词：
Zinc; Hydrosilylation; Amination; Homogeneous catalysis; C=N STRETCHING FREQUENCY; CARBONYL-COMPOUNDS; ASYMMETRIC HYDROSILYLATION; N-ALKYLATION; ENANTIOSELECTIVE HYDROSILYLATION; GREEN CHEMISTRY; CHIRAL LIGANDS; KETONES; ALDEHYDES; EFFICIENT;
D O I：
10.1007/s10562-010-0463-4
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
In the present study, the zinc-catalyzed reductive amination of various aldehydes has been examined in detail. Simple zinc(II) triflate was applied as hydrosilylation catalyst for the reduction of the in situ formed imine by condensation of an aldehyde with an amine. Using a practical Lewis acid catalyst and PMHS [poly(methylhydrosiloxane)] as cheap hydride source excellent yields and a broad functional group tolerance were achieved.
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页码：55 / 61
页数：7
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