Heterogeneous Genetic Location of mcr-1 in Colistin-Resistant Escherichia coli Isolates from Humans and Retail Chicken Meat in Switzerland: Emergence of mcr-1-Carrying IncK2 Plasmids

被引：57

作者：

Dona, Valentina ^{[1
,3
]}

Bernasconi, Odette J. ^{[1
,2
]}

Pires, Joao ^{[1
,2
]}

Collaud, Alexandra ^{[3
]}

Overesch, Gudrun ^{[3
]}

Ramette, Alban ^{[1
]}

Perreten, Vincent ^{[3
]}

Endimiani, Andrea ^{[1
]}

机构：

[1] Univ Bern, Inst Infect Dis, Bern, Switzerland

[2] Univ Bern, Grad Sch Cellular & Biomed Sci, Bern, Switzerland

[3] Univ Bern, Vetsuisse Fac, Inst Vet Bacteriol, Bern, Switzerland

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2017年 / 61卷 / 11期

基金：

瑞士国家科学基金会;

关键词：

colistin; chromosome; E; coli; mcr-1; food; IncK2; Escherichia coli; animals; chromosome organization; humans; meat; plasmids; POULTRY MEAT; ENTEROBACTERIACEAE;

D O I：

10.1128/AAC.01245-17

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We characterized the genetic environment of mcr-1 in colistin-resistant Escherichia coli strains isolated in Switzerland during 2014 to 2016 from humans (n = 3) and chicken meat (n = 6). Whole-genome and plasmid sequencing identified the mcr-1 gene integrated in IncX4 (of which, one strain carried the mcr-1.2 variant), IncI2, IncHI2, and novel IncK2 plasmids (overall, n = 7), as well as in the bacterial chromosome (n = 2) in single or duplicate copies. Our study supports the easy mobilization of mcr-1 across diverse genetic locations.

引用

页数：6

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