Human Plasma Glycome in Attention-Deficit Hyperactivity Disorder and Autism Spectrum Disorders

被引：40

作者：

Pivac, Nela ^{[2
]}

Knezevic, Ana ^{[1
]}

Gornik, Olga ^{[1
]}

Pucic, Maja ^{[3
]}

Igl, Wilmar ^{[4
]}

Peeters, Hilde ^{[5
]}

Crepel, An ^{[5
]}

Steyaert, Jean ^{[5
]}

Novokmet, Mislav ^{[3
]}

Redzic, Irma ^{[1
]}

Nikolac, Matea ^{[2
]}

Hercigonja, Vesna Novkovic ^{[6
]}

Curkovic, Katarina Dodig ^{[7
]}

Curkovic, Mario ^{[8
]}

Nedic, Gordana ^{[2
]}

Muck-Seler, Dorotea ^{[2
]}

Borovecki, Fran ^{[9
]}

Rudan, Igor ^{[10
,11
]}

Lauc, Gordan ^{[1
,3
]}

机构：

[1] Univ Zagreb, Fac Pharm & Biochem, Zagreb 10000, Croatia

[2] Rudjer Boskovic Inst, Div Mol Med, Zagreb 10000, Croatia

[3] Genos Ltd, Glycobiol Div, Zagreb 10000, Croatia

[4] Uppsala Univ, Dept Genet & Pathol, Rudbeck Lab, Uppsala, Sweden

[5] Univ Hosp Leuven, Ctr Human Genet, Louvain, Belgium

[6] Polyclin Kocijan Hercigonja, Zagreb 10000, Croatia

[7] Clin Hosp Osijek, Dept Child & Adolescent Psychiat, Osijek 31000, Croatia

[8] Primary Care Unit Osijek, Osijek 31000, Croatia

[9] Univ Zagreb, Sch Med, Zagreb 10000, Croatia

[10] Univ Split, Croatian Ctr Global Hlth, Sch Med, Split 21000, Croatia

[11] Univ Edinburgh, Sch Med, Ctr Populat Hlth Sci, Edinburgh, Midlothian, Scotland

来源：

MOLECULAR & CELLULAR PROTEOMICS | 2011年 / 10卷 / 01期

关键词：

DEFICIT/HYPERACTIVITY DISORDER; N-GLYCANS; PROTEIN GLYCOSYLATION; GENE; PROFILES; DISEASE; SWEET;

D O I：

10.1074/mcp.M110.004200

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Over a half of all proteins are glycosylated, and their proper glycosylation is essential for normal function. Unfortunately, because of structural complexity of nonlinear branched glycans and the absence of genetic template for their synthesis, the knowledge about glycans is lagging significantly behind the knowledge about proteins or DNA. Using a recently developed quantitative high throughput glycan analysis method we quantified components of the plasma N-glycome in 99 children with attention-deficit hyperactivity disorder (ADHD), 81 child and 5 adults with autism spectrum disorder, and a total of 340 matching healthy controls. No changes in plasma glycome were found to associate with autism spectrum disorder, but several highly significant associations were observed with ADHD. Further structural analysis of plasma glycans revealed that ADHD is associated with increased antennary fucosylation of biantennary glycans and decreased levels of some complex glycans with three or four antennas. The design of this study prevented any functional conclusions about the observed associations, but specific differences in glycosylation appears to be strongly associated with ADHD and warrants further studies in this direction. Molecular & Cellular Proteomics 10: 10.1074/mcp.M110.004200, 1-7, 2011.

引用

页数：7

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