Synthesis, characterization, DNA binding, antibacterial, and antioxidant activity of new bis-phthalimides

被引：17

作者：

Arif, R. ^{[1
]}

Nayab, P. Sirajuddin ^{[1
]}

Rahisuddin, P. ^{[1
]}

机构：

[1] Jamia Millia Islamia, Dept Chem, New Delhi 110025, India

来源：

RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2016年 / 86卷 / 06期

关键词：

Phthalimide derivatives; ct-DNA; antibacterial activity; MOLECULAR DOCKING; N-OXYL; COMPLEXES; ANTICONVULSANT; DERIVATIVES; NI(II); CU(II); CO(II); AGENT; DRUG;

D O I：

10.1134/S1070363216060232

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

New bis-phthalimides were synthesized by 2: 1 condensation of phthalic anhydride and tetrachlorophthalic anhydride with 1,2,4-triazole-3,5-diamine, pyridine-2,6-diamine, and 4-hydroxypyrimidine- 2,6-diamine. The synthesized compounds were characterized by elemental analyses and IR, H-1 NMR, and mass spectra. Their interaction with calf thymus DNA (ct-DNA) was studied by UV-Vis spectrophotometry, cyclic voltammetry, and viscosity measurements, which revealed intercalative mode of binding to ct-DNA. Antibacterial activity of the synthesized compounds against Escherichia coli and Streptococcus mutans was assessed in vitro by the agar well diffusion method. The antioxidant activity of these compounds was estimated by DPPH assay.

引用

页码：1374 / 1380

页数：7

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