Emerging Therapeutic Strategies in Breast Cancer

被引：7

作者：

Cox, Kayla

Alford, Brandon

Soliman, Hatem

机构：

[1] Lake Erie Coll Osteopath Med, Bradenton, FL USA

[2] Univ S Florida, Coll Med, Tampa, FL USA

[3] H Lee Moffitt Canc Ctr & Res Inst, Tampa, FL USA

来源：

SOUTHERN MEDICAL JOURNAL | 2017年 / 110卷 / 10期

关键词：

breast cancer; genomics; immunotherapy; targeted therapy; ESTROGEN-RECEPTOR DEGRADER; RANDOMIZED PHASE-II; MOLECULAR PORTRAITS; 1ST-LINE THERAPY; ESR1; MUTATIONS; DOUBLE-BLIND; DNA-DAMAGE; TRASTUZUMAB; INHIBITOR; TAMOXIFEN;

D O I：

10.14423/SMJ.0000000000000709

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The field of medical oncology is experiencing a period of rapid evolution owing to advances in the fields of genomics, tumor biology, and immunology. These disciplines have provided valuable insights into the heterogeneity between breast tumors, key oncogenic drivers, and the role of the immune system in the natural history of breast cancer. This knowledge is translating into many novel therapeutic strategies using personalized medicines, targeted drug delivery systems, and immunomodulatory agents in the treatment of both the early and metastatic stages of the disease. This review article attempts to cover the major developments in experimental therapeutics and how they relate to our understanding of breast cancer and its various biologic subtypes.

引用

页码：632 / 637

页数：6

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