The inhibitory effects of peripheral administration of peptide YY3-36 and glucagon-like peptide-1 on food intake are attenuated by ablation of the vagal-brainstem-hypothalamic pathway

被引：437
作者：
Abbott, CR [1 ]
Monteiro, M [1 ]
Small, CJ [1 ]
Sajedi, A [1 ]
Smith, KL [1 ]
Parkinson, JRC [1 ]
Ghatei, MA [1 ]
Bloom, SR [1 ]
机构：
[1] Univ London Imperial Coll Sci Technol & Med, Endocrine Unit, London W12 0NN, England
来源：
BRAIN RESEARCH | 2005年 / 1044卷 / 01期
基金：
英国惠康基金;
关键词：
peptide YY; glucagon-like peptide-1; appetite; vagus nerve; brainstein; hypothalamus;
D O I：
10.1016/j.brainres.2005.03.011
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The vagus nerve forms a neuro-anatomical link between the gastrointestinal tract and the brain. A number of gastrointestinal hormones, including cholecystokinin and ghrelin, require an intact vagal-brainstem-hypothalamic pathway to affect CNS feeding circuits. We have, shown that the effects of peripheral administration of both peptide YY3-36 (PYY3-36) and glucagon-like peptide-1 (GLP-1) on food intake and activation of hypothalamic arcuate feeding neurotics are abolished following either bilateral sub-diaphragmatic total truncal vagotomy or brainstem-hypothalamic pathway transectioning in rodents. These findings suggest that the vagal-brainstem-hypothalamic pathway may also play a role in the effects of circulating PYY3-36 and GLP-1 on food intake. (c) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码：127 / 131
页数：5
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