A novel sensitive detection platform for antitumor herbal drug aloe-emodin based on the graphene modified electrode

被引：40

作者：

Li, Juan ^{[1
]}

Chen, Jinghua ^{[1
]}

Zhang, Xiao-Long ^{[1
]}

Lu, Chun-Hua ^{[1
]}

Yang, Huang-Hao ^{[1
]}

机构：

[1] Fuzhou Univ, Coll Chem & Chem Engn, Fujian Prov Key Lab Anal & Detect Technol Food Sa, Key Lab Anal & Detect Technol Food Safety,MOE, Fuzhou 350002, Peoples R China

来源：

TALANTA | 2010年 / 83卷 / 02期

基金：

中国国家自然科学基金; 美国国家科学基金会;

关键词：

Graphene; Modified electrode; Aloe-emodin; Electrochemical determination; ANTHRAQUINONES; INVOLVEMENT; GRAPHITE; AGENT; VERA; GAS;

D O I：

10.1016/j.talanta.2010.09.058

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

This paper has presented a novel strategy to carry out direct and sensitive determination of antitumor herbal drug aloe-emodin in complex matrices based on the graphene-Nafion modified glassy carbon (GN/GC) electrode. This proposed modified electrode showed good electrochemical response towards aloe-emodin (AE). Compared with the multiwall carbon nanotubes (MWCNTs) modified electrode, the GN/GC electrode has the advantages of higher sensitivity and lower cost. Under the optimized conditions, the calibration curve for AE concentration was linear in the range from 5 nmol/L to 1 mu mol/L with the detection limit of 2 nmol/L. In addition, the practical analytical performance of the GN/GC electrode was examined by evaluating the selective detection of AE in natural aloe extracts and human urine samples with satisfied recovery. Therefore, the GN/GC electrode may hold great promise for fast, simple and sensitive detection and biomedical analysis of AE in complex matrices. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：553 / 558

页数：6

共 35 条

[1] Aloe-emodin induced in vitro G2/M arrest of cell cycle in human promyelocytic leukemia HL-60 cells [J].