The Tyrolean early vascular ageing-study (EVA-Tyrol): study protocol for a non-randomized controlled trial Effect of a cardiovascular health promotion program in youth, a prospective cohort study

被引：14

作者：

Bernar, Benoit ^{[1
]}

Gande, Nina ^{[2
]}

Stock, Katharina A. ^{[2
]}

Staudt, Anna ^{[2
]}

Pechlaner, Raimund ^{[1
]}

Geiger, Ralf ^{[3
,4
]}

Griesmacher, Andrea ^{[5
]}

Kiechl, Stefan ^{[1
]}

Knoflach, Michael ^{[1
]}

Kiechl-Kohlendorfer, Ursula ^{[2
]}

Asare, Mandy ^{[1
]}

Bock-Bartl, Manuela ^{[6
]}

Bohl, Maximilian ^{[1
]}

Burger, Christina ^{[6
]}

Broessner, Gregor ^{[1
]}

Heisinger, Tatjana ^{[6
]}

Hochmayr, Christoph ^{[6
]}

Klingenschmid, Julia ^{[6
]}

Kothmayer, Martina ^{[6
]}

Marxer, Julia ^{[6
]}

Pechlaner, Raimund ^{[1
]}

Pircher, Maximilian ^{[6
]}

Reiter, Carmen ^{[6
]}

Kiechl, Sophia J. ^{[1
]}

Winder, Bernhard ^{[6
]}

机构：

[1] Med Univ Innsbruck, Dept Neurol, Anichstr 35, A-6020 Innsbruck, Austria

[2] Med Univ Innsbruck, Dept Pediat 2, Anichstr 35, A-6020 Innsbruck, Austria

[3] Med Univ Innsbruck, Dept Pediat 3, Anichstr 35, A-6020 Innsbruck, Austria

[4] Bruneck Hosp, Dept Pediat, Brunico, Italy

[5] Med Univ Innsbruck, Cent Inst Clin Chem & Lab Med ZIMCL, Anichstr 35, A-6020 Innsbruck, Austria

[6] Med Univ Innsbruck, Dept Pediat Neonatol 2, Innsbruck, Austria

来源：

BMC CARDIOVASCULAR DISORDERS | 2020年 / 20卷 / 01期

关键词：

ATHEROSCLEROSIS RISK-FACTORS; FACTOR INTERVENTION PROJECT; LIFE-STYLE INTERVENTION; EATING BEHAVIOR; FOOD-HABITS; DISEASE; CHILDHOOD; CHILDREN; DIETARY; QUESTIONNAIRE;

D O I：

10.1186/s12872-020-01357-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background According to the World Health Organization, cardiovascular diseases (CVDs) are the leading non-communicable cause of death. Awareness of the individual risk profile is crucial to implement a healthy lifestyle and prevent CVDs. Multiple studies demonstrated that atherosclerosis, the main cause of CVDs, begins early in life. Therefore, it may be necessary to start prevention programs already in childhood. Methods The EVA-Tyrol study is a population-based non-randomized controlled trial that will prospectively enroll 2000 participants from high schools and training companies in North- and East-Tyrol (Austria) and South-Tyrol (Italy). Participants will be assigned to either an intervention (n = 1500) or a control (n = 500) group. Intervention group participants will be enrolled at the 10th school grade (mean age 15-16 years), undergo two examinations within a two-year interval, with follow-up at the 12th grade (mean ages 17-18 years). Control group participants will be enrolled at the 12th grade (mean age 17-18 years). Medical examination will include anthropometric measurements, comprehensive lifestyle and dietary questionnaires, a fasting blood sample, high-resolution ultrasound of the carotid arteries, and measurement of carotid-femoral pulse wave velocity. Active intervention will consist of (1) enhancing knowledge about CVDs, (2) individual medical counseling based on the results of the baseline examination, (3) an online health promotion tool and (4) involvement of participants in planning and implementation of health promotion projects. Effectiveness of the intervention will be assessed by comparing the proportion subjects with ideal health metrics as defined by the American Heart Association between study groups. Discussion This study aims to improve cardiovascular health in Tyrolean adolescents by demonstrating the efficacy of a multi-layer health promotion program and may yield novel insights into the prevalence of vascular risk conditions and mechanisms of early vascular pathologies in adolescents.

引用

页数：10

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