L-DOPA-induced excessive daytime sleepiness in PD -: A placebo-controlled case with MSLT assessment

被引：25

作者：

Garcia-Borreguero, D ^{[1
]}

Schwarz, C ^{[1
]}

Larrosa, O ^{[1
]}

de la Llave, Y ^{[1
]}

de Yébenes, JG ^{[1
]}

机构：

[1] Univ Autonoma Madrid, Fdn Jimenez Diaz, Dept Neurol, Sleep Disorders Unit, Madrid, Spain

来源：

NEUROLOGY | 2003年 / 61卷 / 07期

关键词：

D O I：

10.1212/WNL.61.7.1008

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A 74-year-old patient with idiopathic Parkinson's disease was evaluated for unintended sleep episodes that occurred after long-term treatment with 400 mg/day of L-dopa. Overnight sleep studies and multiple sleep latency testing were carried out under double-blind administration of either L-dopa or placebo. Mean sleep latency with L-dopa was 7 minutes, in contrast to a normal value of 19 minutes, 25 seconds with placebo. The authors' results suggest that L-dopa may cause daytime somnolence in some patients with Parkinson's disease.

引用

页码：1008 / 1010

页数：3

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