The impact of non-coding RNAs on macrophage polarization

被引：49

作者：

Ghafouri-Fard, Soudeh ^{[1
]}

Abak, Atefe ^{[2
]}

Avval, Shamim Tavakkoli ^{[3
]}

Shoorei, Hamed ^{[4
]}

Taheri, Mohammad ^{[5
]}

Samadian, Mohammad ^{[6
]}

机构：

[1] Shahid Beheshti Univ Med Sci, Sch Med, Dept Med Genet, Tehran, Iran

[2] Shahid Beheshti Univ Med Sci, Mens Hlth & Reprod Hlth Res Ctr, Tehran, Iran

[3] Tabriz Islamic Azad Univ, Fac Vet Med, Tabriz, Iran

[4] Birjand Univ Med Sci, Dept Anat Sci, Fac Med, Birjand, Iran

[5] Shahid Beheshti Univ Med Sci, Urol & Nephrol Res Ctr, Tehran, Iran

[6] Shahid Beheshti Univ Med Sci, Loghman Hakim Hosp, Skull Base Res Ctr, Tehran, Iran

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2021年 / 142卷

关键词：

Macrophage polarization; MiRNA; LncRNA; CANCER; ACTIVATION; M1; JAK; MECHANISMS; PLASTICITY; INFECTION; CARCINOMA; AUTOPHAGY; RESPONSES;

D O I：

10.1016/j.biopha.2021.112112

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Macrophage polarization is a process through which macrophages attain unique functional features as a response to certain stimuli from their niche. Lipopolysaccharide and Th1 cytokines induce generation of M1 macrophages. On the other hand, IL-4, IL-13, IL-10, IL-33, and TGF-8 induce polarization of macrophages towards M2 phenotype. This process is also modulated by a number of miRNAs and lncRNAs. miR-375, miR-let7, miR-34a, miR-155, miR-124, miR-34a, miR-511-3p, miR-99a, miR-132 and miR-145-3p are among miRNAs that regulate macrophage polarization. Meanwhile, macrophage polarization is influenced by some lncRNAs such as H19, NRON, MEG3, GAS5, RN7SK, and AK085865. Macrophage polarization has functional significance in a wide range of human disorders particularly immune disorders and cancer. In addition, the effect of certain drugs in modulation of macrophage polarization is exerted through modulation of expression of non-coding RNAs. In the current manuscript, we provide a summary of studies aimed to identification of this aspect of non-coding RNAs.

引用

页数：15

共 118 条

[11] Pioglitazone decreased renal calcium oxalate crystal formation by suppressing M1 macrophage polarization via the PPAR-γ-miR-23 axis [J].