The impact of non-coding RNAs on macrophage polarization

被引：49
作者：
Ghafouri-Fard, Soudeh [1 ]
Abak, Atefe [2 ]
Avval, Shamim Tavakkoli [3 ]
Shoorei, Hamed [4 ]
Taheri, Mohammad [5 ]
Samadian, Mohammad [6 ]
机构：
[1] Shahid Beheshti Univ Med Sci, Sch Med, Dept Med Genet, Tehran, Iran
[2] Shahid Beheshti Univ Med Sci, Mens Hlth & Reprod Hlth Res Ctr, Tehran, Iran
[3] Tabriz Islamic Azad Univ, Fac Vet Med, Tabriz, Iran
[4] Birjand Univ Med Sci, Dept Anat Sci, Fac Med, Birjand, Iran
[5] Shahid Beheshti Univ Med Sci, Urol & Nephrol Res Ctr, Tehran, Iran
[6] Shahid Beheshti Univ Med Sci, Loghman Hakim Hosp, Skull Base Res Ctr, Tehran, Iran
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2021年 / 142卷
关键词：
Macrophage polarization; MiRNA; LncRNA; CANCER; ACTIVATION; M1; JAK; MECHANISMS; PLASTICITY; INFECTION; CARCINOMA; AUTOPHAGY; RESPONSES;
D O I：
10.1016/j.biopha.2021.112112
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Macrophage polarization is a process through which macrophages attain unique functional features as a response to certain stimuli from their niche. Lipopolysaccharide and Th1 cytokines induce generation of M1 macrophages. On the other hand, IL-4, IL-13, IL-10, IL-33, and TGF-8 induce polarization of macrophages towards M2 phenotype. This process is also modulated by a number of miRNAs and lncRNAs. miR-375, miR-let7, miR-34a, miR-155, miR-124, miR-34a, miR-511-3p, miR-99a, miR-132 and miR-145-3p are among miRNAs that regulate macrophage polarization. Meanwhile, macrophage polarization is influenced by some lncRNAs such as H19, NRON, MEG3, GAS5, RN7SK, and AK085865. Macrophage polarization has functional significance in a wide range of human disorders particularly immune disorders and cancer. In addition, the effect of certain drugs in modulation of macrophage polarization is exerted through modulation of expression of non-coding RNAs. In the current manuscript, we provide a summary of studies aimed to identification of this aspect of non-coding RNAs.
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页数：15
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