Nanotherapeutics to Overcome Conventional Cancer Chemotherapy Limitations

被引:380
作者
Moorthi, C. [1 ]
Manavalan, R. [1 ]
Kathiresan, K. [1 ]
机构
[1] Annamalai Univ, Dept Pharm, Chidambaram, Tamil Nadu, India
关键词
COATED PLGA NANOPARTICLES; DRUG-DELIVERY SYSTEMS; MULTIDRUG-RESISTANCE; BREAST-CANCER; MESOPOROUS SILICA; NAB-PACLITAXEL; SOLID TUMORS; FOLIC-ACID; IN-VIVO; CELLS;
D O I
10.18433/J30C7D
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Cancer is one of the major causes of death worldwide and chemotherapy is a major therapeutic approach for the treatment which may be used alone or combined with other forms of therapy. However, conventional chemotherapy suffers lack of aqueous solubility, lack of selectivity and multidrug resistance. Nanotherapeutics is rapidly progressing aimed to solve several limitations of conventional drug delivery systems. Nonspecific target of cancer chemotherapy leads to damage rapidly proliferating normal cells and can be significantly reduced through folate and transferrin mediated nanotherapeutics which are aimed to target cancerous cells. Multidrug resistance is challenge in cancer chemotherapy which can be significantly reversed by solid lipid nanoparticles, polymeric nanoparticles, mesoporous silica nanoparticles, nanoparticulated chemosensitizer, nanoparticluated poloxamer and magnetic nanoparticles. Hydrophobic nature of chemotherapeutics leads to poor aqueous solubility and low bioavailability which can be overcome by nanocrystals, albumin based nanoparticles, liposomal formulation, polymeric micelles, cyclodextrin and chitosan based nanoparticles. This review focuses the role of nanotherapeutics to overcome lack of selectivity, multidrug resistance and lack of aqueous solubility of conventional cancer chemotherapy.
引用
收藏
页码:67 / 77
页数:11
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