Evolutionary genotypes of influenza A (H7N9) viruses over five epidemic waves in China

被引：16

作者：

Ding, Xiao ^{[1
,2
,3
]}

Luo, Jiejian ^{[4
,5
]}

Quan, Lijun ^{[1
,2
,3
]}

Wu, Aiping ^{[1
,2
,3
]}

Jiang, Taijiao ^{[1
,2
,3
]}

机构：

[1] Chinese Acad Med Sci, Inst Basic Med Sci, Ctr Syst Med, Beijing 100005, Peoples R China

[2] Peking Union Med Coll, Beijing 100005, Peoples R China

[3] Suzhou Inst Syst Med, Suzhou Ind Pk,218 Star Lake St, Suzhou 215123, Jiangsu, Peoples R China

[4] Univ Chinese Acad Sci, Beijing, Peoples R China

[5] Chinese Acad Sci, Inst Biophys, Key Lab Prot & Peptide Pharmaceut, Beijing 100101, Peoples R China

来源：

INFECTION GENETICS AND EVOLUTION | 2017年 / 55卷

基金：

中国国家自然科学基金;

关键词：

Influenza virus; H7N9; Evolution; Reassortment; Genotype; Mutation; A(H7N9) VIRUS; HUMAN INFECTIONS; 3RD WAVE; ADAPTATION; POLYMERASE; GENESIS; ORIGIN;

D O I：

10.1016/j.meegid.2017.09.027

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Since the first human case of influenza A (H7N9) infection was identified in March 2013, five epidemics have emerged in China. Diverse H7N9 virus genotypes created through reassortments were already detected in the first epidemic wave, but how the H7N9 virus genetic diversities have evolved during the subsequent epidemics remained unclear. Here, to assess the ongoing genetic evolution of H7N9 viruses, we performed in-depth investigations of the dynamic H7N9 genotypes in these waves. We found that the H7N9 genotypes in the second and third epidemic waves are more diverse than those in the first wave, due to new reassortments that occurred during the second wave. However, the number of different H7N9 genotypes identified in the fourth and fifth waves decreased significantly. Furthermore, we found that different dominant genotypes existed in each of the five epidemic waves, and these wave-specific genotypes possess unique mutations that are enriched in the PB2 protein.

引用

页码：269 / 276

页数：8

共 26 条

[1] BEAST 2: A Software Platform for Bayesian Evolutionary Analysis [J].

Bouckaert, Remco ;

Heled, Joseph ;

Kuehnert, Denise ;

Vaughan, Tim ;

Wu, Chieh-Hsi ;

Xie, Dong ;

Suchard, Marc A. ;

Rambaut, Andrew ;

Drummond, Alexei J. .

PLOS COMPUTATIONAL BIOLOGY, 2014, 10 (04)

[2] Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome [J].

Chen, Yu ;

Liang, Weifeng ;

Yang, Shigui ;

Wu, Nanping ;

Gao, Hainv ;

Sheng, Jifang ;

Yao, Hangping ;

Wo, Jianer ;

Fang, Qiang ;

Cui, Dawei ;

Li, Yongcheng ;

Yao, Xing ;

Zhang, Yuntao ;

Wu, Haibo ;

Zheng, Shufa ;

Diao, Hongyan ;

Xia, Shichang ;

Zhang, Yanjun ;

Chan, Kwok-Hung ;

Tsoi, Hoi-Wah ;

Teng, Jade Lee-Lee ;

Song, Wenjun ;

Wang, Pui ;

Lau, Siu-Ying ;

Zheng, Min ;

Chan, Jasper Fuk-Woo ;

To, Kelvin Kai-Wang ;

Chen, Honglin ;

Li, Lanjuan ;

Yuen, Kwok-Yung .

LANCET, 2013, 381 (9881) :1916-1925

[3] Dynamic reassortments and genetic heterogeneity of the human-infecting influenza A (H7N9) virus [J].

Cui, Lunbiao ;

Liu, Di ;

Shi, Weifeng ;

Pan, Jingcao ;

Qi, Xian ;

Li, Xianbin ;

Guo, Xiling ;

Zhou, Minghao ;

Li, Wei ;

Li, Jun ;

Haywood, Joel ;

Xiao, Haixia ;

Yu, Xinfen ;

Pu, Xiaoying ;

Wu, Ying ;

Yu, Huiyan ;

Zhao, Kangchen ;

Zhu, Yefei ;

Wu, Bin ;

Jin, Tao ;

Shi, Zhiyang ;

Tang, Fenyang ;

Zhu, Fengcai ;

Sun, Qinglan ;

Wu, Linhuan ;

Yang, Ruifu ;

Yan, Jinghua ;

Lei, Fumin ;

Zhu, Baoli ;

Liu, Wenjun ;

Ma, Juncai ;

Wang, Hua ;

Gao, George F. .

NATURE COMMUNICATIONS, 2014, 5

[4] jModelTest 2: more models, new heuristics and parallel computing [J].

Darriba, Diego ;

Taboada, Guillermo L. ;

Doallo, Ramon ;

Posada, David .

NATURE METHODS, 2012, 9 (08) :772-772

[5] CD-HIT: accelerated for clustering the next-generation sequencing data [J].

Fu, Limin ;

Niu, Beifang ;

Zhu, Zhengwei ;

Wu, Sitao ;

Li, Weizhong .

BIOINFORMATICS, 2012, 28 (23) :3150-3152

[6] Human Infection with a Novel Avian-Origin Influenza A (H7N9) Virus [J].

Gao, Rongbao ;

Cao, Bin ;

Hu, Yunwen ;

Feng, Zijian ;

Wang, Dayan ;

Hu, Wanfu ;

Chen, Jian ;

Jie, Zhijun ;

Qiu, Haibo ;

Xu, Ke ;

Xu, Xuewei ;

Lu, Hongzhou ;

Zhu, Wenfei ;

Gao, Zhancheng ;

Xiang, Nijuan ;

Shen, Yinzhong ;

He, Zebao ;

Gu, Yong ;

Zhang, Zhiyong ;

Yang, Yi ;

Zhao, Xiang ;

Zhou, Lei ;

Li, Xiaodan ;

Zou, Shumei ;

Zhang, Ye ;

Li, Xiyan ;

Yang, Lei ;

Guo, Junfeng ;

Dong, Jie ;

Li, Qun ;

Dong, Libo ;

Zhu, Yun ;

Bai, Tian ;

Wang, Shiwen ;

Hao, Pei ;

Yang, Weizhong ;

Zhang, Yanping ;

Han, Jun ;

Yu, Hongjie ;

Li, Dexin ;

Gao, George F. ;

Wu, Guizhen ;

Wang, Yu ;

Yuan, Zhenghong ;

Shu, Yuelong .

NEW ENGLAND JOURNAL OF MEDICINE, 2013, 368 (20) :1888-1897

[7] Association between adverse clinical outcome in human disease caused by novel influenza A H7N9 virus and sustained viral shedding and emergence of antiviral resistance [J].

Hu, Yunwen ;

Lu, Shuihua ;

Song, Zhigang ;

Wang, Wei ;

Hao, Pei ;

Li, Jianhua ;

Zhang, Xiaonan ;

Yen, Hui-Ling ;

Shi, Bisheng ;

Li, Tao ;

Guan, Wencai ;

Xu, Lei ;

Liu, Yi ;

Wang, Sen ;

Zhang, Xiaoling ;

Tian, Di ;

Zhu, Zhaoqin ;

He, Jing ;

Huang, Kai ;

Chen, Huijie ;

Zheng, Lulu ;

Li, Xuan ;

Ping, Jie ;

Kang, Bin ;

Xi, Xiuhong ;

Zha, Lijun ;

Li, Yixue ;

Zhang, Zhiyong ;

Peiris, Malik ;

Yuan, Zhenghong .

LANCET, 2013, 381 (9885) :2273-2279

[8] Increase in Human Infections with Avian Influenza A(H7N9) Virus During the Fifth Epidemic - China, October 2016-February 2017 [J].

Iuliano, A. Danielle ;

Jang, Yunho ;

Jones, Joyce ;

Davis, C. Todd ;

Wentworth, David E. ;

Uyeki, Timothy M. ;

Roguski, Katherine ;

Thompson, Mark G. ;

Gubareva, Larisa ;

Fry, Alicia M. ;

Burns, Erin ;

Track, Susan ;

Zhou, Suizan ;

Katz, Jacqueline M. ;

Jernigan, Daniel B. .

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT, 2017, 66 (09) :254-255

[9]

Kageyama T, 2013, EUROSURVEILLANCE, V18, P7

[10] Dissemination, divergence and establishment of H7N9 influenza viruses in China [J].

Lam, Tommy Tsan-Yuk ;

Zhou, Boping ;

Wang, Jia ;

Chai, Yujuan ;

Shen, Yongyi ;

Chen, Xinchun ;

Ma, Chi ;

Hong, Wenshan ;

Chen, Yin ;

Zhang, Yanjun ;

Duan, Lian ;

Chen, Peiwen ;

Jiang, Junfei ;

Zhang, Yu ;

Li, Lifeng ;

Poon, Leo Lit Man ;

Webby, Richard J. ;

Smith, David K. ;

Leung, Gabriel M. ;

Peiris, Joseph S. M. ;

Holmes, Edward C. ;

Guan, Yi ;

Zhu, Huachen .

NATURE, 2015, 522 (7554) :102-U265

← 1 2 3 →