Synthesis of a New Class of Chiral Maleimide Derivatives with C2-Symmetry

被引：0

作者：

Fu, Liyan ^{[1
,2
]}

Ji, Baoming ^{[1
]}

Du, Chenxia ^{[2
]}

机构：

[1] Luoyang Normal Univ, Coll Chem & Chem Engn, Luoyang 471022, Peoples R China

[2] Zhengzhou Univ, Coll Chem & Mol Engn, Zhengzhou 450001, Henan, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 37卷 / 10期

基金：

中国国家自然科学基金;

关键词：

imide; BINOL; organic synthesis; chirality; PROTECTING GROUP; EPOXIDES;

D O I：

10.6023/cjoc201703001

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Starting from the readily available maleic anhydride and (R)-1,1'-bi-2-naphthol (BINOL), an efficient method for the synthesis of a new class of chiral maleimide derivatives with C-2-symmetry was described, involving Williamson ether synthesis, Suzuki coupling reaction and deprotection reaction by microwave to give 3,4-[(R)-3,3'-diaryl-1,1'-binaphthyl-2,2'-dioxy]-maleimides in 6.2%similar to 16% yields. Moreover, the structures of the target compound and key intermediates were confirmed by H-1 NMR, C-13 NMR, HRMS and IR techniques.

引用

页码：2685 / 2689

页数：5

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