The kinetic resolution of oxazinones by alcoholysis: access to orthogonally protected β-amino acids

被引：4
|
作者：
Cronin, Sarah A. [1 ]
Connon, Stephen J. [1 ]
机构：
[1] Trinity Coll Dublin, Trinity Biomed Sci Inst, Sch Chem, Dublin, Ireland
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2021年 / 19卷 / 34期
基金：
爱尔兰科学基金会;
关键词：
ENANTIOSELECTIVE SYNTHESIS; ASYMMETRIC-SYNTHESIS; MESO-ANHYDRIDES; ORGANOCATALYSTS; AZLACTONES; PEPTIDES; DESYMMETRIZATION; CYCLOADDITIONS; CISPENTACIN; DERIVATIVES;
D O I：
10.1039/d1ob01306h
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The catalytic, alcoholytic kinetic resolution of oxazinones is reported. A novel, stereochemically dense cinchona alkaloid-based catalyst can facilitate the highly enantiodiscriminatory (S up to 101) ring-opening of oxazinones equipped with electrophilic aryl units to generate orthogonally protected beta-amino acids for the first time.
引用
收藏
页码：7348 / 7352
页数：5
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