Anti-β2GPI domain 1 antibodies stratify high risk of thrombosis and late pregnancy morbidity in a large cohort of Chinese patients with antiphospholipid syndrome

被引：18

作者：

Liu, Tingting ^{[1
]}

Gu, Jieyu ^{[1
]}

Wan, Liyan ^{[1
]}

Hu, Qiongyi ^{[1
]}

Teng, Jialin ^{[1
]}

Liu, Honglei ^{[1
]}

Cheng, Xiaobing ^{[1
]}

Ye, Junna ^{[1
]}

Su, Yutong ^{[1
]}

Sun, Yue ^{[1
]}

Chi, Huihui ^{[1
]}

Zhou, Zhuochao ^{[1
]}

Jia, Jinchao ^{[1
]}

Wang, Zhihong ^{[1
]}

Zhou, Jinfeng ^{[2
]}

Norman, Gary L. ^{[3
]}

Wang, Xuefeng ^{[4
]}

Yang, Chengde ^{[1
]}

Shi, Hui ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Rheumatol & Immunol, 197 Ruijin Second Rd, Shanghai 200025, Peoples R China

[2] Werfen China, 10 Jiuxianqiao RD, Beijing, Peoples R China

[3] Inova Diagnost Inc, 9900 Old Grove Rd, San Diego, CA 92131 USA

[4] Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Lab Med, Shanghai, Peoples R China

来源：

THROMBOSIS RESEARCH | 2020年 / 185卷

基金：

中国国家自然科学基金;

关键词：

Antiphospholipid syndrome; Anti-beta; 2GP1; domain; 1; antibodies; Thrombosis; Pregnancy morbidity; Global Anti-Phospholipid Syndrome Score; GAPSS; INTERNATIONAL CONSENSUS STATEMENT; SYNDROME SCORE AGAPSS; IGG ANTIBODIES; CLASSIFICATION CRITERIA; BETA(2)-GLYCOPROTEIN I; AUTOANTIBODIES; PREVALENCE; CATEGORIES; UPDATE;

D O I：

10.1016/j.thromres.2019.11.029

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Introduction: Anti-beta 2GPI-Domain 1 (beta 2GPI-D1) antibodies are considered to be a pathogenic subset of anti-beta 2GPI antibodies and have been strongly associated with thrombosis and pregnancy morbidity in patients with antiphospholipid syndrome (APS). We evaluated the clinical utility of anti-beta 2GPI-D1 IgG antibodies for stratifying the risk of thrombosis and/or pregnancy morbidity (PM) in a cohort of Chinese patients with APS and also assessed its correlation with the Global Anti-Phospholipid Syndrome Score (GAPSS). Materials and methods: Sera and plasma from 192 consecutive APS patients, 17 aPL carriers, 193 patients with other systemic autoimmune diseases, and 120 healthy controls were collected and the presence of aCL IgG/IgM, anti-beta 2GPI IgG/IgM and anti-beta 2GPI-D1 IgG antibodies were assessed by chemiluminescence assays (CIA). Detection of LAC was performed according to international guidelines with the use of screening, mixing and confirmation tests. Anti-phosphatidylserine-prothrombin (aPS/PT) IgG and IgM antibodies were detected by commercial ELISA kits. Results: Anti-beta 2GPI-D1 IgG antibodies showed high specificity (97.12%) and moderate sensitivity (64.32%) for the diagnosis of APS. Anti-beta 2GPI-D1 antibodies levels were significantly higher in patients with triple aPL positivity than in those with double (P < 0.001) and single positive aPL (P < 0.001) and correlated well with the GAPSS (rho = 0.60, P < 0.001). Anti-beta 2GPI-D1 antibodies presented with a higher prevalence and higher titers in patients with late pregnancy morbidity (>= 10 weeks) and thrombotic APS compared to those with early pregnancy (< 10 weeks) morbidity. Higher anti-beta 2GP1-D1 antibodies titers effectively distinguished APS from other autoimmune diseases. Conclusion: This study suggests a predictive role of anti-beta 2GPI-D1 IgG antibodies as a strong risk factor for both thrombotic and obstetric APS (OAPS), especially for stratification comparing early PM with late PM and thrombosis.

引用

页码：142 / 149

页数：8