The Effect of Moringa Oleifera Leaf Extract on Mean Platelet Volume and Neutrophil-to-Lymphocyte Ratio in Autoimmune Patients

Background: Moringa oleifera is one of the promising novel treatments in autoimmune diseases through anti-inflammation and immunosuppression. Mean platelet volume and neutrophil-to-lymphocyte ratio are used to measure the degree of inflammation. This study aimed to identify the effect of Moringa oleifera leaf extract on the mean platelet volume and neutrophil-lymphocyte ratio in autoimmune patients. Research methods: This experimental study was conducted on 30 autoimmune patients consisting of 28 lupus patients and 2 rheumatoid arthritis patients of the rheumatology clinic at Moewardi General Hospital in January-March 2019. The patient was grouped into two, the treatment and control groups. The patients were in the treatment group received 2 grams of Moringa oleifera leaf extract per day, while those in the control group received a placebo. The study was conducted for 4 weeks, concluded with an evaluation. MPV (mean platelet volume) and NLR (neutrophil-to-lymphocyte ratio) examination used a haemocytometer. Statistical analysis was performed using paired T-test and independent T-test. The p-value was considered significant when p < 0.05. Results: The results showed that Moringa oleifera leaf extract decreases MPV (delta MPV = 4.141; r = 0.656; p-value = 0.02) and Neutrophil-to-lymphocyte ratio (delta NLR = 4.1391; r 0.489; p-value = 0.04). Conclusion: The study revealed that Moringa oleifera leaf extract decreased mean platelet volume and neutrophil-to-lymphocyte ratio in autoimmune patients.