A Functional Circuit for the Retrieval of Remote Cued Fear Memory

被引:7
|
作者
Todd, Travis P. [1 ]
Jiang, Matthew Y. [1 ]
DeAngeli, Nicole E. [1 ]
Bucci, David J. [1 ]
机构
[1] Dartmouth Coll, Dept Psychol & Brain Sci, 6207 Moore Hall, Hanover, NH 03755 USA
基金
美国国家卫生研究院; 美国国家科学基金会;
关键词
retrosplenial; auditory cortex; remote memory; fear conditioning; RETROSPLENIAL CORTEX; BASOLATERAL AMYGDALA; NEUROTOXIC LESIONS; CONNECTIONS; CORTICES; RAT; CONTEXT; RECEPTORS;
D O I
10.1037/bne0000237
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Although the retrosplenial cortex (RSC) is necessary for the retrieval of remotely acquired fear to a discrete auditory cue, it is not necessary for the retrieval of recently acquired cued-fear memories. Thus, the RSC's role in memory retrieval for discrete cues is time-dependent. The purpose of the current experiment was to identify the larger cortical circuit involved in the retrieval of remotely-acquired auditory fear memories. One candidate circuit involves the RSC and secondary auditory cortex; the secondary auditory cortex is also necessary for the retrieval of remotely acquired auditory fear memories (Sacco & Sacchetti, 2010), and sends direct projections to the RSC. To test this possibility, we assessed retrieval of remote memory following functional disconnection of the RSC and secondary auditory cortex. Complete disconnection of these regions produced a larger impairment in fear expression to a remotely acquired auditory cue compared to partial disconnection of these regions. These results are consistent with the notion that RSC and secondary auditory cortex form a functional circuit involved in the retrieval of remotely acquired fear to a discrete auditory cue.
引用
收藏
页码:403 / 408
页数:6
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