Nanoengineered polymer capsules:: Tools for detection, controlled delivery, and site-specific manipulation

被引:237
|
作者
Sukhorukov, GB [1 ]
Rogach, AL
Zebli, B
Liedl, T
Skirtach, AG
Köhler, K
Antipov, AA
Gaponik, N
Susha, AS
Winterhalter, M
Parak, WJ
机构
[1] Max Planck Inst Colloids & Interface, D-14424 Potsdam, Germany
[2] Univ Munich, Photon & Optoelect Grp, Dept Phys, D-80799 Munich, Germany
[3] Univ Munich, Ctr Nanosci CeNS, D-80799 Munich, Germany
[4] Univ Hamburg, Inst Chem Phys, D-20146 Hamburg, Germany
[5] Int Jacobs Univ Bremen, Sch Sci & Engn, D-28759 Bremen, Germany
[6] Inst Pharmacol & Biol Struct, F-31077 Toulouse, France
关键词
biomaterials; drug delivery; microcapsules; polyelectrolytes; quantum dots;
D O I
10.1002/smll.200400075
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The aim of nanobiotechnology is the discovery of new drug and their delivery systems, including building up of multifunctional capsules as intelligent drug carriers: once injected somewhere into blood stream the capsules would find their target, is discussed. The combination of physical, chemical, and biological approaches for designing the capsule properties is necessary to develop the capsule technology towards biological applications. It is suggested that the development of multifunctional carrier system will design surfaces and interior composition as delivery systems with (remote) stimuli-controlled release will have a strong impact on biotechnology. With multifunctionasl capsules, direction and control of the uptake of drugs by pathological cells with different methods is possible.
引用
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页码:194 / 200
页数:7
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