Further insights in the mechanisms of interleukin-1β stimulation of osteoprotegerin in osteoblast-like cells

被引：22
作者：
Lambert, Cecile
Oury, Cecile
Dejardin, Emmanuel
Chariot, Alain
Piette, Jacques
Malaise, Michel
Merville, Marie-Paule
Franchimont, Nathalie
机构：
[1] Univ Liege, Ctr Biomed Integrat Genoproteom CBIG, Dept Rheumatol, Liege, Belgium
[2] Univ Liege, Ctr Biomed Integrat Genoproteom CBIG, Lab Med Chem & Human Genet, Liege, Belgium
[3] Univ Liege, Ctr Biomed Integrat Genoproteom CBIG, Virol & Immunol Unit, Liege, Belgium
来源：
JOURNAL OF BONE AND MINERAL RESEARCH | 2007年 / 22卷 / 09期
关键词：
osteoprotegerin; interleukin-1; beta; NF-kappa B; osteoblast; apoptosis;
D O I：
10.1359/JBMR.070508
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The mechanisms of IL-1 beta stimulation of OPG were studied in more detail. Whereas p38 and ERK activation was confirmed to be needed, NF-kappa B was not necessary for this regulation. We also found that OPG production after IL-1 beta stimulation was not sufficient to block TRAIL-induced apoptosis in MG-63 cells.
引用
收藏
页码：1350 / 1361
页数：12
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