Synthesis, Crystal Structure and Biological Activity of 2-Chloro-5-(((5-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)methyl)thiazole

被引：14
|
作者：
Shen Zhong-Hua [1 ]
Zhai Zhi-Wen [1 ]
Sun Zhao-Hui [1 ]
Weng Jian-Quan [1 ]
Tan Cheng-Xia [1 ]
Liu Xing-Hai [1 ]
机构：
[1] Zhejiang Univ Technol, Coll Chem Engn, Hangzhou 310014, Zhejiang, Peoples R China
来源：
CHINESE JOURNAL OF STRUCTURAL CHEMISTRY | 2017年 / 36卷 / 07期
关键词：
pyrazole; synthesis; crystal structure; biological activities; heterocycles; ANTIFUNGAL ACTIVITY; NEMATOCIDAL ACTIVITY; HERBICIDAL ACTIVITY; DERIVATIVES; ANTIBACTERIAL; DESIGN;
D O I：
10.14102/j.cnki.0254-5861.2011-1488
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The title compound 5-chloro-2-(((5-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-4-phenyl-4H-1,2,4-triazol-3-yl) thio) methyl) thiazole (C17H12ClF3N6S2) was synthesized, and its structure was confirmed by H-1 NMR, C-13 NMR, HRMS and X-ray diffraction. It crystallizes in the triclinic system, space group P (1) over bar with a = 8.214(5), b = 10.188(6), c = 12.378(7) angstrom, alpha = 81.679(8), beta = 87.994(8), gamma = 70.351(8)degrees, D-c = 1.572 g/cm(3), Z = 2, V = 965.2(9) angstrom(3), the final R = 0.0591 and wR = 0.1113 for 3005 observed reflections with I > 2 sigma(I). The preliminary biological test shows that the title compound possesses good herbicidal activities (80%) against rape at 200 mu g/mL.
引用
收藏
页码：1137 / 1141
页数：5
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