International consensus recommendations on the aesthetic usage of botulinum toxin type A (Speywood Unit) - part I: upper facial wrinkles

被引：77

作者：

Ascher, B. ^{[1
]}

Talarico, S. ^{[2
]}

Cassuto, D. ^{[3
]}

Escobar, S. ^{[4
]}

Hexsel, D. ^{[5
]}

Jaen, P. ^{[6
]}

Monheit, G. D. ^{[7
]}

Rzany, B. ^{[8
]}

Viel, M. ^{[9
]}

机构：

[1] Clin Chirurg Esthet Lena, Paris, France

[2] Univ Fed San Paulo, Sao Paulo, Brazil

[3] Univ Catania, Milan, Italy

[4] Univ Buenos Aires, Buenos Aires, DF, Argentina

[5] Pontificia Univ Catol Rio Grande Sul, Porto Alegre, RS, Brazil

[6] Ramon & Cajal Publ Hosp, Madrid, Spain

[7] Total Skin & Beauty Dermatol Ctr, Birmingham, AL USA

[8] Charite, Dermatol Klin, dEBM, D-13353 Berlin, Germany

[9] London Ctr Aesthet Surg, London, England

来源：

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY | 2010年 / 24卷 / 11期

关键词：

botulinum toxin type A; consensus; facial wrinkle; Speywood; GLABELLAR LINES; DOUBLE-BLIND; CROWS FEET; EFFICACY; SAFETY; DYSPORT; MULTICENTER; INJECTIONS; BOTOX;

D O I：

10.1111/j.1468-3083.2010.03631.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Background Azzalure (Galderma SA) is a newly approved European botulinum neurotoxin type A (BoNT-A). It is derived from Dysport (Ipsen Pharma), which has a long history of usages in various applications. Azzalure and Dysport are collectively referred to as BoNT-A (Speywood Unit) and are different from other BoNT-A preparations. Objective To provide consensus recommendations on the treatment of upper face wrinkles with BoNT-A (Speywood Unit). Methods The members of the International Board on Botulinum toxin Azzalure (IBBA) convened to develop consensus on the treatment of upper facial wrinkles based on their own extensive experience. Results The consensus recommendations address the general issues regarding treatment and provide specific guidelines on the anatomy, injection points, dose, injection technique and safety precautions concerning each common upper face indication. The recommended final concentration of BoNT-A (Speywood Unit) is 200 s.U/mL (10 s.U/0.05 mL) after reconstitution. For glabellar lines, the members recommend a total of five injection points with 10 s.U/point. For forehead wrinkles, the members recommend four to six injections into the frontalis with 5-10 s.U/point. For crow's feet, the members recommend three injections per side with 5-10 s.U/point at the lateral part of the orbicularis oculi. For lateral eyebrow lift, the members recommend one point at each eyebrow tail and an additional one in each side of the frontalis with 5-10 s.U/point. Conclusion This guideline provides a framework for physicians who wish to perform safe and efficacious injection of BoNT-A (Speywood Unit).

引用

页码：1278 / 1284

页数：7

共 34 条

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