Protective effect and mechanism of Shenkang injection on adenine-induced chronic renal failure in rats

被引:7
作者
Chen, Rongchang [1 ,2 ]
Xu, Lijiao [1 ,2 ]
Zhang, Xu [1 ,2 ]
Sun, Guibo [1 ,2 ]
Zeng, Wenying [3 ]
Sun, Xiaobo [1 ,2 ]
机构
[1] Peking Union Med Coll, Beijing, Peoples R China
[2] Chinese Acad Med Sci, Inst Med Plant Dev, Beijing, Peoples R China
[3] Xiyuan Hosp, Dept Comprehens Med, Beijing, Peoples R China
关键词
Kidney Failure; Chronic; Fibrosis; Rats; ALLEVIATES OXIDATIVE STRESS; FIBROSIS; INFLAMMATION; NEPHROPATHY; CHILDREN; MODEL;
D O I
10.1590/acb370304
中图分类号
R61 [外科手术学];
学科分类号
摘要
Purpose: To investigate the protective effects of Shenkang injection (SKI) on adenine-induced chronic renal failure (CRF) in rat. Methods: Sprague Dawley rats were randomly divided into five groups: control, model, and SKI groups (5, 10, 20 mL/kg). Rats in model and SKI groups were treated with adenine i.g. at a dose of 150 mg/kg every day for 12 weeks to induce CRF. Twelve weeks later, SKI was administered to the rat i.p. for four weeks. The effects of SKI on kidney injury and fibrosis were detected. Results: SKI inhibited the elevation of the urine level of N-acetyl-b-D-glucosaminidase, kidney injury molecule-1, beta-2-microglobulin, urea protein in CRF rats. The serum levels of uric acid and serum creatinine increased and albumin decreased in the model group, which was prevented by SKI. SKI inhibited the release of inflammatory cytokines and increasing the activities of antioxidant enzymes in serum. SKI inhibited the expression of transforming growth factor-beta 1, vascular cell adhesion molecule 1, intercellular adhesion molecule 1, collagen I, collagen III, endothelin- 1, laminin in kidney of CRF rats. Conclusion: SKI protected against adenine-induced kidney injury and fibrosis and exerted anti-inflammatory, and antioxidant effects in CRF rats.
引用
收藏
页数:10
相关论文
共 24 条
  • [11] High salt aggravates renal inflammation via promoting pro-inflammatory macrophage in 5/6-nephrectomized rat
    Liu, Yang
    Dai, Xiaoyan
    Yang, Shaohua
    Peng, Yan
    Hou, Fanfan
    Zhou, Qiugen
    [J]. LIFE SCIENCES, 2021, 274
  • [12] Liu YL, 2019, AM J TRANSL RES, V11, P1980
  • [13] Baicalin Alleviates Oxidative Stress and Inflammation in Diabetic Nephropathy via Nrf2 and MAPK Signaling Pathway
    Ma, Leyi
    Wu, Fan
    Shao, Qingqing
    Chen, Guang
    Xu, Lijun
    Lu, Fuer
    [J]. DRUG DESIGN DEVELOPMENT AND THERAPY, 2021, 15 : 3207 - 3221
  • [14] Effects of calcitriol and paricalcitol on renal fibrosis in CKD
    Martinez-Arias, Laura
    Panizo, Sara
    Alonso-Montes, Cristina
    Martin-Virgala, Julia
    Martin-Carro, Beatriz
    Fernandez-Villabrille, Sara
    Garcia Gil-Albert, Carmen
    Palomo-Antequera, Carmen
    Luis Fernandez-Martin, Jose
    Piedad Ruiz-Torres, Maria
    Dusso, Adriana S.
    Carrillo-Lopez, Natalia
    Cannata-Andia, Jorge B.
    Naves-Diaz, Manuel
    [J]. NEPHROLOGY DIALYSIS TRANSPLANTATION, 2021, 36 (05) : 793 - 803
  • [15] A systematic analysis of worldwide population-based data on the global burden of chronic kidney disease in 2010
    Mills, Katherine T.
    Xu, Yu
    Zhang, Weidong
    Bundy, Joshua D.
    Chen, Chung-Shiuan
    Kelly, Tanika N.
    Chen, Jing
    He, Jiang
    [J]. KIDNEY INTERNATIONAL, 2015, 88 (05) : 950 - 957
  • [16] Serum VCAM-1, ICAM-1, and L-selectin levels in children and young adults with chronic renal failure
    Musial, K
    Zwolinska, D
    Polak-Jonkisz, D
    Berny, U
    Szprynger, K
    Szczepanska, M
    [J]. PEDIATRIC NEPHROLOGY, 2005, 20 (01) : 52 - 55
  • [17] Antioxidant, anti-inflammatory and renoprotective effects of acidic-hydrolytic polysaccharides by spent mushroom compost (Lentinula edodes) on LPS-induced kidney injury
    Song, Xinling
    Ren, Zhenzhen
    Wang, Xiuxiu
    Jia, Le
    Zhang, Chen
    [J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2020, 151 : 1267 - 1276
  • [18] Mechanisms of Metabolic Acidosis-Induced Kidney Injury in Chronic Kidney Disease
    Wesson, Donald E.
    Buysse, Jerry M.
    Bushinsky, David A.
    [J]. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2020, 31 (03): : 469 - 482
  • [19] ShenKang injection suppresses kidney fibrosis and oxidative stress via transforming growth factor-/Smad3 signalling pathway in vivo and in vitro
    Wu, Xiaoxiao
    Guan, Yue
    Yan, Jiajia
    Liu, Meiyou
    Yin, Ying
    Duan, Jialin
    Wei, Guo
    Hu, Tianxin
    Weng, Yan
    Xi, Miaomiao
    Wen, Aidong
    [J]. JOURNAL OF PHARMACY AND PHARMACOLOGY, 2015, 67 (08) : 1054 - 1065
  • [20] Scutellarin protects against myocardial ischemia-reperfusion injury by suppressing NLRP3 inflammasome activation
    Xu, Li-jiao
    Chen, Rong-chang
    Ma, Xiao-yu
    Zhu, Yue
    Sun, Gui-bo
    Sun, Xiao-bo
    [J]. PHYTOMEDICINE, 2020, 68