MicroRNAs are potential prognostic and therapeutic targets in diabetic osteoarthritis

被引：22
|
作者：
Shi Jingsheng [1 ]
Wei Yibing [1 ]
Xia Jun [1 ]
Wang Siqun [1 ]
Wu Jianguo [1 ]
Chen Feiyan [1 ]
Huang Gangyong [1 ]
Chen Jie [1 ]
机构：
[1] Fudan Univ, Huashan Hosp, Dept Orthoped, Shanghai 200040, Peoples R China
来源：
JOURNAL OF BONE AND MINERAL METABOLISM | 2015年 / 33卷 / 01期
关键词：
MicroRNA; Type II diabetes; Osteoarthritis chondrocyte; GLYCATION END-PRODUCTS; MESENCHYMAL PROGENITOR CELLS; ARTICULAR-CARTILAGE; STEM-CELLS; CHONDROGENIC DIFFERENTIATION; CHONDROCYTE PROLIFERATION; ELEVATED MICRORNA-34A; KNEE OSTEOARTHRITIS; MEDIATED REGULATION; EXPRESSION;
D O I：
10.1007/s00774-014-0628-0
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Osteoarthritis is an aging-related degenerative disease that severely influences the elders' life quality. However, there have been few clinical approaches available until now. Currently, more knowledge of the pathology of osteoarthritis has been illustrated. Especially, diabetes can be the only predictor of osteoarthritis. Due to its outstanding characteristics, MicroRNA has been considered as an efficient target in treating diseases. In this review, we will discuss a new insight focusing on the roles of microRNA in the progression of osteoarthritis-induced by diabetes, especially type II diabetes mellitus.
引用
收藏
页码：1 / 8
页数：8
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