ncRDense: A novel computational approach for classification of non-coding RNA family by deep learning

被引:12
|
作者
Chantsalnyam, Tuvshinbayar [1 ]
Siraj, Arslan [1 ]
Tayara, Hilal [2 ]
Chong, Kil To [1 ,3 ]
机构
[1] Jeonbuk Natl Univ, Dept Elect & Informat Engn, Jeonju 54896, South Korea
[2] Jeonbuk Natl Univ, Sch Int Engn & Sci, Jeonju 54896, South Korea
[3] Jeonbuk Natl Univ, Adv Elect & Informat Res Ctr, Jeonju 54896, South Korea
基金
新加坡国家研究基金会;
关键词
Deep learning; Densenet; Classification; Non-coding RNA; Feature encoding; IDENTIFICATION;
D O I
10.1016/j.ygeno.2021.07.004
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
With the rapidly growing importance of biological research, non-coding RNAs (ncRNA) attract more attention in biology and bioinformatics. They play vital roles in biological processes such as transcription and translation. Classification of ncRNAs is essential to our understanding of disease mechanisms and treatment design. Many approaches to ncRNA classification have been developed, several of which use machine learning and deep learning. In this paper, we construct a novel deep learning-based architecture, ncRDense, to effectively classify and distinguish ncRNA families. In a comparative study, our model produces comparable results with existing state-of-the-art methods. Finally, we built a freely accessible web server for the ncRDense tool, which is available at http://nsclbio.jbnu.ac.kr/tools/ncRDense/.
引用
收藏
页码:3030 / 3038
页数:9
相关论文
共 50 条
  • [21] A Review of Computational Methods for Finding Non-Coding RNA Genes
    Abbas, Qaisar
    Raza, Syed Mansoor
    Biyabani, Azizuddin Ahmed
    Jaffar, Muhammad Arfan
    GENES, 2016, 7 (12)
  • [22] Non-coding RNA
    Mattick, JS
    Makunin, IV
    HUMAN MOLECULAR GENETICS, 2006, 15 : R17 - R29
  • [23] Editorial: Computational approaches for non-coding RNA prediction studies
    Qu, Jia
    Cheng, Xiao-Long
    FRONTIERS IN MOLECULAR BIOSCIENCES, 2022, 9
  • [24] Classification of Long Non-Coding RNAs s Between Early and Late Stage of Liver Cancers From Non-coding RNA Profiles Using Machine-Learning Approach
    Anuntakarun, Songtham
    Khamjerm, Jakkrit
    Tangkijvanich, Pisit
    Chuaypen, Natthaya
    BIOINFORMATICS AND BIOLOGY INSIGHTS, 2024, 18
  • [25] Deep forest ensemble learning for classification of alignments of non-coding RNA sequences based on multi-view structure representations
    Li, Ying
    Zhang, Qi
    Liu, Zhaoqian
    Wang, Cankun
    Han, Siyu
    Ma, Qin
    Du, Wei
    BRIEFINGS IN BIOINFORMATICS, 2021, 22 (04)
  • [26] Non-coding RNAs in virology: an RNA genomics approach
    Isaac, Christopher
    Patel, Trushar R.
    Zovoilis, Athanasios
    BIOTECHNOLOGY AND GENETIC ENGINEERING REVIEWS, VOL 34, ISSUE 1, 2018, 34 (01): : 90 - 106
  • [27] Cancer subtypes classification using long non-coding RNA
    Flippot, Ronan
    Malouf, Gabriel G.
    Su, Xiaoping
    Mouawad, Roger
    Spano, Jean-Philippe
    Khayat, David
    ONCOTARGET, 2016, 7 (33) : 54082 - 54093
  • [28] ncRDeep: Non-coding RNA classification with convolutional neural network
    Chantsalnyam, Tuvshinbayar
    Lim, Dae Yeong
    Tayara, Hilal
    Chong, Kil To
    COMPUTATIONAL BIOLOGY AND CHEMISTRY, 2020, 88
  • [29] A novel non-coding DNA family in Caenorhabditis elegans
    Takashima, Yasuo
    Bando, Tetsuya
    Kagawa, Hiroaki
    GENE, 2007, 388 (1-2) : 61 - 73
  • [30] RNA-Sequencing Approach for the Identification of Novel Long Non-Coding RNA Biomarkers in Colorectal Cancer
    Yamada, Atsushi
    Okugawa, Yoshinaga
    Boland, C. R.
    Goel, Ajay
    GASTROENTEROLOGY, 2015, 148 (04) : S354 - S354