Reduction of hippocampal Na+, K+-ATPase activity in rats subjected to an experimental model of depression

被引：94
作者：
Gamaro, GD [1 ]
Streck, EL [1 ]
Matté, C [1 ]
Prediger, ME [1 ]
Wyse, ATS [1 ]
Dalmaz, C [1 ]
机构：
[1] Univ Fed Rio Grande Sul, Dept Bioquim, ICBS, BR-90035003 Porto Alegre, RS, Brazil
来源：
NEUROCHEMICAL RESEARCH | 2003年 / 28卷 / 09期
关键词：
Na+; K(+-)ATPase; fluoxetine; chronic mild stress; hippocampus; depression;
D O I：
10.1023/A:1024988113978
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The effect of a model of depression using female rats on Na+, K+-ATPase activity in hippocampal synaptic plasma membranes was studied. In addition, the effect of further chronic treatment with fluoxetine on this enzyme activity was verified. Sweet food consumption was measured to evaluate the efficacy of this model in inducing a state of reduced response to rewarding stimili. After 40 days of mild stress, a reduction in sweet food ingestion was observed. Reduction of hippocampal Na+, K+-ATPase activity was also observed. Treatment with fluoxetine increased this enzyme activity and reversed the effect of stress. Chronic fluoxetine decreased the ingestion of sweet food in both groups. This result is in agreement with suggestions that reduction of Na+, K+-ATPase activity is a caracteristic of depressive disorders. Fluoxetine reversed this effect. Therefore it is possible that altered Na+, K+-ATPase activity may be involved in the pathophysiology of depression in patients.
引用
收藏
页码：1339 / 1344
页数：6
相关论文
共 50 条
  • [1] Reduction of Hippocampal Na+, K+-ATPase Activity in Rats Subjected to an Experimental Model of Depression
    Giovana D. Gamaro
    Emilio L. Streck
    Cristiane Matté
    Martha E. Prediger
    Angela T. S. Wyse
    Carla Dalmaz
    Neurochemical Research, 2003, 28 : 1339 - 1344
  • [2] Reduction of Na+,K+-ATPase activity in hippocampus of rats subjected to chemically induced hyperhomocysteinemia
    Streck, EL
    Matte, C
    Vieira, PS
    Rombaldi, F
    Wannmacher, CMD
    Wajner, M
    Wyse, ATS
    NEUROCHEMICAL RESEARCH, 2002, 27 (12) : 1593 - 1598
  • [3] Na+, K+-ATPase activity is increased in rats subjected to chronic administration of ketamine
    De Luca, Renata D.
    Fraga, Daiane de B.
    Ghedim, Fernando V.
    Kolling, Janaina
    Ferreira, Andrea G. K.
    Cunha, Aline A.
    Wyse, Angela T. S.
    Zugno, Alexandra I.
    ACTA NEUROPSYCHIATRICA, 2011, 23 (05): : 215 - 218
  • [4] Reduction of Na+,K+-ATPase Activity in Hippocampus of Rats Subjected to Chemically Induced Hyperhomocysteinemia
    Emílio L. Streck
    Cristiane Matte
    Paula S. Vieira
    Fernanda Rombaldi
    Clóvis M. D. Wannmacher
    Moacir Wajner
    Angela T. S. Wyse
    Neurochemical Research, 2002, 27 : 1593 - 1598
  • [5] Na+,K+-ATPase activity in an animal model of mania
    Zugno, Alexandra I.
    Valvassori, Samira S.
    Scherer, Emilene B. S.
    Mattos, Cristiane
    Matte, Cristiane
    Ferreira, Camila L.
    Rezin, Gislaine T.
    Wyse, Angela T. S.
    Quevedo, Joao
    Streck, Emilio L.
    JOURNAL OF NEURAL TRANSMISSION, 2009, 116 (04) : 431 - 436
  • [6] Na+,K+-ATPase activity is reduced in hippocampus of rats submitted to an experimental model of depression:: Effect of chronic lithium treatment and possible involvement in learning deficits
    de Vasconcellos, APS
    Zugno, AI
    dos Santos, AHDP
    Nietto, FB
    Crema, LM
    Gonçalves, M
    Franzon, R
    Wyse, ATD
    da Rocha, ER
    Dalmaz, C
    NEUROBIOLOGY OF LEARNING AND MEMORY, 2005, 84 (02) : 102 - 110
  • [7] Na+/K+-ATPase: Activity and inhibition
    Colovic, M.
    Krstic, D.
    Krinulovic, K.
    Momic, T.
    Savic, J.
    Vujacic, A.
    Vasic, V.
    RUSSIAN JOURNAL OF PHYSICAL CHEMISTRY A, 2009, 83 (09) : 1602 - 1608
  • [8] Arginine administration inhibits hippocampal Na+,K+-ATPase activity and impairs retention of an inhibitory avoidance task in rats
    dos Reis, EA
    de Oliveira, LS
    Lamers, ML
    Netto, CA
    Wyse, ATD
    BRAIN RESEARCH, 2002, 951 (02) : 151 - 157
  • [9] L-Cysteine and glutathione restore the reduction of rat hippocampal Na+, K+-ATPase activity induced by aspartame metabolites
    Simintzi, Irene
    Schulpis, Kleopatra H.
    Angelogianni, Panagoula
    Liapi, Charis
    Tsakiris, Stylianos
    TOXICOLOGY, 2007, 237 (1-3) : 177 - 183
  • [10] Alanine prevents the decrease of Na+,K+-ATPase activity in experimental phenylketonuria
    Wyse, ATS
    Noriler, ME
    Borges, LF
    Floriano, PJ
    Silva, CG
    Wajner, M
    Wannmacher, CMD
    METABOLIC BRAIN DISEASE, 1999, 14 (02) : 95 - 101
12345