DNA vaccines for veterinary medicine.

被引:0
作者
Gerdts, V
Mettenleiter, TC
机构
[1] Bundesforschungsanstalt Viruskrankeiten Tiere, Friedrich Loeffler Inst, Inst Mol Biol, D-17498 Insel Riems, Germany
[2] Univ Saskatchewan, Vet Infect Dis Org, Saskatoon, SK S7N 0W0, Canada
来源
DEUTSCHE TIERARZTLICHE WOCHENSCHRIFT | 2001年 / 108卷 / 01期
关键词
review; DNA vaccines; immunology;
D O I
暂无
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
DNA vaccination represents one of the most recent novel approaches to vaccine development. Experimentally, DNA vaccines induce a broad range of long lasting immune responses including humoral and cell-mediated immunity against infectious diseases in humans and animals. Furthermore, DNA vaccines are potentially useful for the treatment of autoimmune diseases or cancer. However, most information on the efficacy of DNA vaccines has been generated in mice and studies in larger animals are limited. In this review, the potential application of DNA vaccines in livestock and pet animals are discussed. The principle of this new technology, its potency and future perspectives for use in veterinary medicine will be outlined.
引用
收藏
页码:3 / 10
页数:8
相关论文
共 98 条
  • [51] CpG motifs present in bacterial DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma
    Klinman, DM
    Yi, AK
    Beaucage, SL
    Conover, J
    Krieg, AM
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (07) : 2879 - 2883
  • [52] CPG MOTIFS IN BACTERIAL-DNA TRIGGER DIRECT B-CELL ACTIVATION
    KRIEG, AM
    YI, AK
    MATSON, S
    WALDSCHMIDT, TJ
    BISHOP, GA
    TEASDALE, R
    KORETZKY, GA
    KLINMAN, DM
    [J]. NATURE, 1995, 374 (6522) : 546 - 549
  • [53] Induction of mucosal immunity against herpes simplex virus by plasmid DNA immunization
    Kuklin, N
    Daheshia, M
    Karem, K
    Manickan, E
    Rouse, BT
    [J]. JOURNAL OF VIROLOGY, 1997, 71 (04) : 3138 - 3145
  • [54] Antibody and cellular immune responses of swine following immunisation with plasmid DNA encoding the PRRS virus ORF's 4, 5, 6 and 7
    Kwang, J
    Zuckermann, F
    Ross, G
    Yang, S
    Osorio, F
    Liu, W
    Low, S
    [J]. RESEARCH IN VETERINARY SCIENCE, 1999, 67 (02) : 199 - 201
  • [55] Study of the delivery of the gD gene of pseudorabies virus to one-day-old piglets by adenovirus or plasmid DNA as ways to by-pass the inhibition of immune response by colostral antibodies
    LePotier, MF
    Monteil, M
    Houdayer, C
    Eloit, M
    [J]. VETERINARY MICROBIOLOGY, 1997, 55 (1-4) : 75 - 80
  • [56] Altering the cellular location of an antigen expressed by a DNA-based vaccine modulates the immune response
    Lewis, PJ
    Littel-van den Hurk, SV
    Babiuk, LA
    [J]. JOURNAL OF VIROLOGY, 1999, 73 (12) : 10214 - 10223
  • [57] Immunization of neonates with DNA encoding a bovine herpesvirus glycoprotein is effective in the presence of maternal antibodies
    Littel-van den Hurk, SV
    Braun, RP
    Lewis, PJ
    Karvonen, BC
    Babiuk, LA
    Griebel, PJ
    [J]. VIRAL IMMUNOLOGY, 1999, 12 (01) : 67 - 77
  • [58] Littel-van den Hurk SV, 1998, J GEN VIROL, V79, P831
  • [59] Immunization of the female genital tract with a DNA-based vaccine
    Livingston, JB
    Lu, S
    Robinson, H
    Anderson, DJ
    [J]. INFECTION AND IMMUNITY, 1998, 66 (01) : 322 - 329
  • [60] Gene gun-mediated DNA immunization primes development of mucosal immunity against bovine herpesvirus 1 in cattle
    Loehr, BI
    Willson, P
    Babiuk, LA
    Littel-van den Hurk, SV
    [J]. JOURNAL OF VIROLOGY, 2000, 74 (13) : 6077 - 6086