Autoimmune Pancreatitis with Gastric Cancer: Some IgG4-related Diseases May Be Paraneoplastic Syndrome

被引：7

作者：

Miyagawa, Koichiro ^{[1
]}

Kumamoto, Keiichiro ^{[1
]}

Shinohara, Nobuhiko ^{[1
]}

Watanabe, Tatsuyuki ^{[1
]}

Kumei, Shinsuke ^{[1
]}

Yoneda, Akitoshi ^{[1
]}

Nebuya, Satoru ^{[1
]}

Koya, Yudai ^{[1
]}

Oe, Shinji ^{[1
]}

Kume, Keiichiro ^{[1
]}

Yoshikawa, Ichiro ^{[2
]}

Harada, Masaru ^{[1
]}

机构：

[1] Univ Occupat & Environm Hlth, Sch Med, Dept Internal Med 3, Kitakyushu, Fukuoka, Japan

[2] Univ Hosp Occupat & Environm Hlth, Dept Endoscopy, Kitakyushu, Fukuoka, Japan

来源：

INTERNAL MEDICINE | 2022年 / 61卷 / 14期

关键词：

autoimmune pancreatitis; early gastric cancer; paraneoplastic syndrome; DIAGNOSIS; RISK; MALIGNANCIES; ASSOCIATION; MECHANISMS; CARCINOMA;

D O I：

10.2169/internalmedicine.8590-21

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 70-year-old man was referred to our department for the treatment of early gastric cancer. Contrastenhanced computed tomography (CT) incidentally showed diffuse enlargement of the pancreas with a capsule-like rim, and blood tests showed elevated serum IgG4 levels, leading to a diagnosis of autoimmune pancreatitis (AIP). Endoscopic treatment for gastric cancer was performed, and pathological findings showed adenocarcinoma with abundant IgG4-positive plasma cell infiltration. Thereafter, the serum IgG4 levels normalized, and the findings of AIP disappeared on CT without steroid treatment. These findings suggest that the gastric cancer activated an IgG4-related immune response, resulting in the development of AIP.

引用

页码：2155 / 2160

页数：6

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