1,10-Phenanthroline platinum(II) complex: a simple molecule for efficient G-quadruplex stabilization

被引：48
|
作者：
Wang, Jin-Tao [1 ]
Zheng, Xiao-Hui [1 ]
Xia, Qing [2 ]
Mao, Zong-Wan [1 ,2 ]
Ji, Liang-Nian [1 ]
Wang, Kui [2 ]
机构：
[1] Sun Yat Sen Univ, MOE Key Lab Bioinorgan & Synthet Chem, Sch Chem & Chem Engn, Guangzhou 510275, Guangdong, Peoples R China
[2] Peking Univ, State Key Lab Nat & Biomimet Drug, Dept Biol Chem, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
来源：
DALTON TRANSACTIONS | 2010年 / 39卷 / 31期
基金：
中国国家自然科学基金;
关键词：
TELOMERASE ACTIVITY; QUARTET STRUCTURES; NUCLEIC-ACIDS; DNA; LIGANDS; INHIBITION; DERIVATIVES; PROMOTER; SEQUENCE; TARGETS;
D O I：
10.1039/c0dt00211a
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Two simple complexes [Pt(phen)(2)](PF6)(2) and [Pt(bpy)(2)](PF6)(2) exhibit high stabilization potential for G-quadruplex DNA with [Pt(phen)(2)](PF6)(2) possessing higher capability due to its greater planarity.
引用
收藏
页码：7214 / 7216
页数：3
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