DNA ADENINE METHYLATION;
RESTRICTION-MODIFICATION SYSTEMS;
ESCHERICHIA-COLI CHROMOSOME;
PYELONEPHRITIS-ASSOCIATED PILI;
RESPONSIVE REGULATORY PROTEIN;
PHASE-VARIATION;
SALMONELLA-ENTERICA;
YERSINIA-PSEUDOTUBERCULOSIS;
DAM METHYLTRANSFERASE;
VIRULENCE PLASMID;
D O I:
10.1038/s41579-019-0286-2
中图分类号:
Q93 [微生物学];
学科分类号:
071005 ;
100705 ;
摘要:
In all domains of life, genomes contain epigenetic information superimposed over the nucleotide sequence. Epigenetic signals control DNA-protein interactions and can cause phenotypic change in the absence of mutation. A nearly universal mechanism of epigenetic signalling is DNA methylation. In bacteria, DNA methylation has roles in genome defence, chromosome replication and segregation, nucleoid organization, cell cycle control, DNA repair and regulation of transcription. In many bacterial species, DNA methylation controls reversible switching (phase variation) of gene expression, a phenomenon that generates phenotypic cell variants. The formation of epigenetic lineages enables the adaptation of bacterial populations to harsh or changing environments and modulates the interaction of pathogens with their eukaryotic hosts.
机构:
Univ Calif Santa Barbara, Dept Mol Cellular & Dev Biol, Santa Barbara, CA 93106 USAUniv Calif Santa Barbara, Dept Mol Cellular & Dev Biol, Santa Barbara, CA 93106 USA
Badie, G
Heithoff, DM
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Santa Barbara, Dept Mol Cellular & Dev Biol, Santa Barbara, CA 93106 USAUniv Calif Santa Barbara, Dept Mol Cellular & Dev Biol, Santa Barbara, CA 93106 USA
Heithoff, DM
Mahan, MJ
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Santa Barbara, Dept Mol Cellular & Dev Biol, Santa Barbara, CA 93106 USAUniv Calif Santa Barbara, Dept Mol Cellular & Dev Biol, Santa Barbara, CA 93106 USA
机构:
Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY 10029 USA
Icahn Sch Med Mt Sinai, Icahn Inst Genom & Multiscale Biol, New York, NY 10029 USAIcahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY 10029 USA
Beaulaurier, John
Schadt, Eric E.
论文数: 0引用数: 0
h-index: 0
机构:
Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY 10029 USA
Icahn Sch Med Mt Sinai, Icahn Inst Genom & Multiscale Biol, New York, NY 10029 USAIcahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY 10029 USA
Schadt, Eric E.
Fang, Gang
论文数: 0引用数: 0
h-index: 0
机构:
Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY 10029 USAIcahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY 10029 USA
机构:
Univ Calif Santa Barbara, Dept Mol Cellular & Dev Biol, Santa Barbara, CA 93106 USAUniv Calif Santa Barbara, Dept Mol Cellular & Dev Biol, Santa Barbara, CA 93106 USA
Badie, G
Heithoff, DM
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Santa Barbara, Dept Mol Cellular & Dev Biol, Santa Barbara, CA 93106 USAUniv Calif Santa Barbara, Dept Mol Cellular & Dev Biol, Santa Barbara, CA 93106 USA
Heithoff, DM
Mahan, MJ
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Santa Barbara, Dept Mol Cellular & Dev Biol, Santa Barbara, CA 93106 USAUniv Calif Santa Barbara, Dept Mol Cellular & Dev Biol, Santa Barbara, CA 93106 USA
机构:
Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY 10029 USA
Icahn Sch Med Mt Sinai, Icahn Inst Genom & Multiscale Biol, New York, NY 10029 USAIcahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY 10029 USA
Beaulaurier, John
Schadt, Eric E.
论文数: 0引用数: 0
h-index: 0
机构:
Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY 10029 USA
Icahn Sch Med Mt Sinai, Icahn Inst Genom & Multiscale Biol, New York, NY 10029 USAIcahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY 10029 USA
Schadt, Eric E.
Fang, Gang
论文数: 0引用数: 0
h-index: 0
机构:
Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY 10029 USAIcahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY 10029 USA