Bacterial cytotoxins: Targeting eukaryotic switches

被引：177
作者：
Aktories, K
Barbieri, JT
机构：
[1] Univ Freiburg, Inst Expt & Klin Pharmakol & Toxikol, D-79104 Freiburg, Germany
[2] Med Coll Wisconsin, Dept Microbiol & Mol Genet, Milwaukee, WI 53226 USA
来源：
NATURE REVIEWS MICROBIOLOGY | 2005年 / 3卷 / 05期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1038/nrmicro1150
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Many bacterial cytotoxins act on eukaryotic cells by targeting the regulators that are involved in controlling the cytoskeleton or by directly modifying actin, with members of the Rho GTPase family being particularly important targets. The actin cytoskeleton, and especially the GTPase 'molecular switches' that are involved in its control, have crucial functions in innate and adaptive immunity, and have pivotal roles in the biology of infection. In this review, we briefly discuss the role of the actin cytoskeleton and the Rho GTPases in host-pathogen interactions, and review the mode of actions of bacterial protein toxins that target these components.
引用
收藏
页码：397 / 410
页数：14
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