The role of neuronal signaling in controlling cerebral blood flow

被引：122
作者：
Drake, Carrie T. [1 ]
Iadecola, Costantino [1 ]
机构：
[1] Cornell Univ, Weill Med Coll, Div Neurobiol, Dept Neurol & Neurosci, New York, NY 10128 USA
来源：
BRAIN AND LANGUAGE | 2007年 / 102卷 / 02期
关键词：
functional hyperemia; cerebral blood flow; neurovascular unit; BOLD;
D O I：
10.1016/j.bandl.2006.08.002
中图分类号：
R36 [病理学]; R76 [耳鼻咽喉科学];
学科分类号：
100104 ; 100213 ;
摘要：
Well-regulated blood flow within the brain is vital to normal function. The brain's requirement for sufficient blood flow is ensured by a tight link between neural activity and blood flow. The link between regional synaptic activity and regional cerebral blood flow, termed functional hyperemia, is the basis for several modern imaging techniques that have revolutionized the study of human brain activity. Here, we review the mechanisms of functional hyperemia and their implications for interpreting the blood oxygen level-dependent (BOLD) contrast signal used in functional magnetic resonance imaging (fMRI). (c) 2006 Elsevier Inc. All rights reserved.
引用
收藏
页码：141 / 152
页数：12
相关论文
共 50 条
  • [31] CEREBRAL BLOOD-FLOW, CEREBRAL BLOOD-FLOW REACTIVITY TO ACETAZOLAMIDE, AND CEREBRAL BLOOD-VOLUME IN PATIENTS WITH LEUKOARAIOSIS
    TURC, JD
    CHOLLET, F
    BERRY, I
    SABATINI, U
    DEMONET, JF
    CELSIS, P
    MARCVERGNES, JP
    RASCOL, A
    CEREBROVASCULAR DISEASES, 1994, 4 (04) : 287 - 293
  • [32] The Unexpected Role of the Endothelial Nitric Oxide Synthase at the Neurovascular Unit: Beyond the Regulation of Cerebral Blood Flow
    Scarpellino, Giorgia
    Brunetti, Valentina
    Berra-Romani, Roberto
    De Sarro, Giovambattista
    Guerra, Germano
    Soda, Teresa
    Moccia, Francesco
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 (16)
  • [33] Angiotensin and Cerebral Blood Flow
    Juan M. Saavedra
    Yasuaki Nishimura
    Cellular and Molecular Neurobiology, 1999, 19 : 553 - 573
  • [34] Cerebral blood flow in the neonate
    Vutskits, Laszlo
    PEDIATRIC ANESTHESIA, 2014, 24 (01) : 22 - 29
  • [35] Angiotensin and cerebral blood flow
    Saavedra, JM
    Nishimura, Y
    CELLULAR AND MOLECULAR NEUROBIOLOGY, 1999, 19 (05) : 553 - 573
  • [36] Multifractality of cerebral blood flow
    West, BJ
    Latka, M
    Glaubic-Latka, M
    Latka, D
    PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS, 2003, 318 (3-4) : 453 - 460
  • [37] The relationship between cerebral blood flow and volume in humans
    Rostrup, E
    Knudsen, GM
    Law, I
    Holm, S
    Larsson, HBW
    Paulson, OB
    NEUROIMAGE, 2005, 24 (01) : 1 - 11
  • [38] Astrocyte regulation of cerebral blood flow during hypoglycemia
    Nippert, Amy R.
    Chiang, Pei-Pei
    Del Franco, Armani P.
    Newman, Eric A.
    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2022, 42 (08) : 1534 - 1546
  • [39] Control of Cerebral Blood Flow by Blood Gases
    Duffin, James
    Mikulis, David J.
    Fisher, Joseph A.
    FRONTIERS IN PHYSIOLOGY, 2021, 12
  • [40] The role of endothelin-1 in pressure autoregulation of cerebral blood flow in rats
    L. Mascia
    I. R. Piper
    P. J. D. Andrews
    M. J. Souter
    D. J. Webb
    Intensive Care Medicine, 1999, 25 : 1282 - 1286
12345