Three new cytotoxic Diels-Alder-type adducts from Morus australis

被引：49

作者：

Zhang, Qing-Jian ^{[1
]}

Tang, Yan-Bo ^{[1
]}

Chen, Ruo-Yun ^{[1
]}

Yu, De-Quan ^{[1
]}

机构：

[1] Chinese Acad Med Sci, Inst Mat Med, Minist Educ,Peking Union Med Coll, Key Lab Bioact Subst & Resources Utilizat Chinese, Beijing 100050, Peoples R China

来源：

CHEMISTRY & BIODIVERSITY | 2007年 / 4卷 / 07期

关键词：

D O I：

10.1002/cbdv.200790133

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Three new natural products, australisines A-C (1-3, resp.), were isolated from the stem bark of Morus australis, together with eight related compounds, including mulberrofurans E-G, J, and Q, mongolicin C, chalcomoracin, and kuwanon G. Their structures were fully characterized by spectroscopic methods. Compounds 1-3, mulberrofuran G, mongolicin C, and chalcomoracin showed moderate cytotoxic activities against five human cancer cell lines, with IC50 values ranging from 4.6-9.2 mu g/ml, as determined by MTT assay.

引用

页码：1533 / 1540

页数：8

共 11 条

[1] Bioactive Diels-Alder type adducts from the stem bark of Morus macroura [J].