Highly enantioselective dynamic kinetic resolution and desymmetrization processes by cyclocondensation of chiral aminoalcohols with racemic or prochiral δ-oxoacid derivatives

被引：31
作者：
Amat, M [1 ]
Bassas, O
Pericàs, MA
Pastó, M
Bosch, J
机构：
[1] Univ Barcelona, Fac Pharm, Organ Chem Lab, E-08028 Barcelona, Spain
[2] Univ Barcelona, Dept Organ Chem, E-08028 Barcelona, Spain
来源：
CHEMICAL COMMUNICATIONS | 2005年 / 10期
关键词：
D O I：
10.1039/b413937b
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Cyclocondensation reactions of aminoalcohols 7 and 8 with racemic or prochiral delta-oxoacid derivatives provide polysubstituted lactams with high enantioselectivity in a process that involves dynamic kinetic resolution and/or desymmetrization of enantiotopic or diastereotopic ester groups.
引用
收藏
页码：1327 / 1329
页数：3
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