The Impact of Genes on Adolescent Substance Use: a Developmental Perspective

被引:11
作者
Trucco, Elisa M. [1 ]
Madan, Brigitte [2 ]
Villar, Michelle [2 ]
机构
[1] Florida Int Univ, Dept Psychol, Ctr Children & Families, 11200 SW 8th St,AHC-1, Miami, FL 33199 USA
[2] Florida Int Univ, Ctr Children & Families, 11200 SW 8th St,AHC-4, Miami, FL 33199 USA
基金
美国国家卫生研究院;
关键词
Adolescence; Genes; Gene x environment; Substance use; Intermediate phenotypes; Neurogenetics;
D O I
10.1007/s40429-019-00273-z
中图分类号
R194 [卫生标准、卫生检查、医药管理];
学科分类号
摘要
Purpose of ReviewThis review discusses the importance of understanding the impact of genetic factors on adolescent substance use within a developmental framework. Methods for identifying genetic factors, relevant endophenotypes and intermediate phenotypes, and gene-environment interplay effects will be reviewed.Recent FindingsPrior work supports the role of polygenic variation on adolescent substance use. Mechanisms through which genes impact adolescent phenotypes consist of differences in neural structure and function, early temperamental differences, and problem behavior. Gene-environment interactions are characterized by increased vulnerability to both maladaptive and adaptive contexts.SummaryDevelopmental considerations in genetic investigations highlight the critical role that polygenic variation has on adolescent substance use. Yet, determining what to do with this information, especially in terms of personalized medicine, poses ethical and logistic challenges.
引用
收藏
页码:522 / 531
页数:10
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