Elevated concentrations of circulating cytokines and correlations with nerve conduction velocity in human peripheral nerves

被引：1
|
作者：
Allison, David J. [1 ]
Green, Lara A. [1 ]
Gabriel, David A. [1 ]
Roy, Brian D. [1 ]
Inglis, J. Greig [1 ]
Ditor, David S. [1 ]
机构：
[1] Brock Univ, Dept Kinesiol, St Catharines, ON L2S 3A1, Canada
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2014年 / 277卷 / 1-2期
关键词：
Channelopathy; Nerve conduction velocity; Interleukin-6; Interleukin-1ra; Interleukin-10; Tumor necrosis factor-alpha; NECROSIS-FACTOR-ALPHA; SPINAL-CORD-INJURY; PROINFLAMMATORY CYTOKINES; INFLAMMATORY HYPERALGESIA; HEART-RATE; INTERLEUKIN-6; RELIABILITY; MECHANISMS; RAT; AUTOANTIBODIES;
D O I：
10.1016/j.jneuroim.2014.09.010
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The purpose of the current study was to quantify the potential relationship between various cytokines and peripheral nerve function in humans, in-vivo. Measures of nerve conduction velocity (NCV) were examined prior to and following the induction of a cytokine spike. A significant negative correlation was found between the change in IL-1ra and the change in NCV at 24 h post-exercise (r = -0.65, p = 0.02) while a significant positive correlation was found between the change in IL-6 and the change in NCV at 2 h post-exercise (r = 0.61, p = 0.048). It may be possible that different cytokines induce a unique neural influence at elevated concentrations. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码：134 / 139
页数：6
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