Isoflavone-rich soy protein prevents loss of hip lean mass but does not prevent the shift in regional fat distribution in perimenopausal women

被引:42
|
作者
Moeller, LE
Peterson, CT
Hanson, KB
Dent, SB
Lewis, DS
King, DS
Alekel, DL
机构
[1] Iowa State Univ Sci & Technol, Dept Food Sci & Human Nutr, Human Metab Unit, Ctr Designing Foods Improve Nutr, Ames, IA 50011 USA
[2] Univ Iowa, Roy J Lucille A Carver Coll Med, Iowa City, IA 52242 USA
[3] Iowa State Univ Sci & Technol, Dept Stat, Ames, IA 50011 USA
[4] Iowa State Univ Sci & Technol, Dept Hlth & Human Performance, Ames, IA 50011 USA
[5] Calif State Polytech Univ Pomona, Dept Human Nutr & Food Sci, Pomona, CA 91768 USA
来源
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY | 2003年 / 10卷 / 04期
关键词
dual energy x-ray absorptiometry; insulin; insulin-like growth factor; perimenopausal women; regional fat distribution; soy isoflavones;
D O I
10.1097/01.GME.0000054763.94658.FD
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: Menopause-induced estrogen deficiency increases the risk of cardiovascular disease, which is related to a shift in regional fat distribution. We tested the hypothesis that estrogen-like isoflavones in soy protein isolate (SPI+) would lessen both regional fat gain and lean loss compared with isoflavone-poor soy (SPI-). Design: Perimenopausal participants (N = 69) were randomly assigned (double-blind) to 24 weeks of treatment (40 g soy or whey protein per day): SPI+ (n = 24), SPI- (n = 24), or whey control (n = 2 1); each participant had blood drawn in the fasted (12 hours) state, had physical activity assessed, and kept a 5-day food diary. Dual-energy x-ray absorptiometry was used to examine the effects of SPI+ on regional fat and lean tissue distribution changes in the waist, hip, and thigh regions. Results: Mean body mass increased (P < 0.01) in each group, but treatment had no effect on gain in overall body mass, fat mass, or lean mass using analysis of variance. In all treatment groups combined, lean mass increased in each region; fat mass increased only in the waist region. Treatment had an effect (P = 0.039) on hip lean mass and a marginal effect (P = 0.077) on thigh fat. Regression analyses revealed that SPI+ diminished the increase in thigh fat (P = 0.018) and heightened the increase in hip lean (P = 0.035) mass. Carbohydrate intake (P = 0.006) and cohort (reflective of season; P = 0.011) contributed to the gain in thigh fat. Total protein intake (P = 0.0012), plasma insulin (P = 0.0034), and physical activity (P = 0.047) contributed to the gain in hip lean mass. Conclusions: Gain in hip lean mass was greater (P = 0.014) in SPI+ than other groups, but SPI+ did not reduce the disease-promoting menopausal shift in regional fat mass.
引用
收藏
页码:322 / 331
页数:10
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